Results 141 to 150 of about 581,117 (305)

Corrigendum: Systems pharmacology approach to investigate the mechanism of Kai-Xin-San in Alzheimer’s disease

Frontiers in Pharmacology, 2023
Yunxia Luo, Yunxia Luo, Dongli Li, Yanfang Liao, Chuipu Cai, Qihui Wu, Hanzhong Ke, Hanzhong Ke, Xinning Liu, Huilin Li, Honghai Hong, Yumin Xu, Qi Wang, Qi Wang, Jiansong Fang, Jiansong Fang, Shuhuan Fang, Shuhuan Fang   +17 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Clinical Pharmacology in the UK, c.1950-2000: Industry and Regulation [PDF]

, 2008
Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.First published by the Wellcome Trust Centre for the ...
Reynolds, LA, Tansey, EM
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

NovelHTI: An Interpretable Pathway-Enhanced Framework for De Novo Target Prediction of Medicinal Herbs via Cross-Scale Heterogeneous Information Fusion

Pharmaceuticals
Background: The modernization of Traditional Chinese Medicine (TCM) is hindered by a “structure-blind” bottleneck: establishing molecular mechanisms for complex formulations with uncharacterized chemical constituents. Conventional computational screening
Yuyam Cheung
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Systems Pharmacology in a Nutshell

, 2020
Chris Rackauckas ...
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

SLC26A9 in triple-negative breast cancer stem cells: a network pharmacology and molecular modeling study

Frontiers in Bioengineering and Biotechnology
Triple-negative breast cancer (TNBC) presents significant clinical challenges due to its high heterogeneity and lack of effective targeted therapies.
Mimi Shen, Mimi Shen, Zhiyuan Ma, Yanghui Cao, Lan Wang, Guoli Feng, Guoli Feng, Zhengxing Zhou, Zhengxing Zhou, Leilei Li, Leilei Li, Bei Ji, Shuhui Liu, Jiaqi Qin, Qin Wang, Xuemei Liu, Taolang Li, Taolang Li   +17 more
doaj   +1 more source