Results 181 to 190 of about 313,523 (292)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Archaeogenetic insights into the demographic history of Late Neanderthals. [PDF]

Proc Natl Acad Sci U S A
Fotiadou CM, Pedersen JB, Rougier H, Roksandic M, Spyrou MA, Nägele K, Reiter E, Bocherens H, Kandel AW, Haidle MN, Streicher TP, Conard NJ, Schilt F, Godinho RM, Uthmeier T, Doyon L, Semal P, Krause J, Barbieri A, Mihailović D, Crevecoeur I, Posth C.   +21 more
europepmc   +1 more source

Review of \u3cem\u3eRevolution, Idealism, and Human Freedom: Schelling, Hölderlin, and Hegel and the Crisis of Early German Idealism\u3c/em\u3e by Franz Gabriel Nauen [PDF]

, 1974
Vater, Michael
core   +1 more source

59. Satzmodus [PDF]

, 1993
Altmann, Hans, Jacobs, Joachim
core   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Bacterial diet influences mutation rate in Pristionchus pacificus. [PDF]

G3 (Bethesda)
Wang Y, Theam P, Quiobe SP, Röseler W, Witte H, Rödelsperger C, Sommer RJ.   +6 more
europepmc   +1 more source

Journey to Work Travel Outcomes from ‘City of Short Distances’ Compact City Planning in Tübingen, Germany

, 2018
I. Hamiduddin
semanticscholar   +1 more source

Real‐world management of adjuvant systemic melanoma therapy: Multi‐center survey of 51 DeCOG skin cancer centers

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Adjuvant immune checkpoint inhibitors (ICI) and targeted therapy (TT) have revolutionized treatment management for patients with melanoma. However, the current German S3 guideline does not differentiate between patients with and without adjuvant therapy in its recommendations for imaging intervals and follow‐up monitoring, leading to
Markus Reitmajer, Elisabeth Livingstone, Lucie Heinzerling, Kai‐Martin Thoms, Frank Meiss, Markus V. Heppt, Anja Gesierich, Konstantin Drexler, Friedegund Meier, Max Schlaak, Andrea Forschner, Lisa Zimmer   +11 more
wiley   +1 more source

Leveraging large language models to populate structured clinical case report forms from unstructured medical notes in radiation oncology. [PDF]

Clin Transl Radiat Oncol
Nachbar M, Yi N, Büttner M, Gani C, Niyazi M, Garcia-Agundez A, Eickhoff C, Thorwarth D.   +7 more
europepmc   +1 more source

National Delphi consensus on laser and energy‐based treatments for rosacea

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Various treatments are available for rosacea, including lasers and energy‐based devices (EBDs). However, the specific role of lasers and EBDs in rosacea management remains insufficiently defined in Germany. The aim of the study was to develop a comprehensive expert consensus on the use of lasers and EBDs in the treatment of rosacea ...
Lynhda Nguyen, Nikolaus Seeber, Uwe Paasch, Martin Schaller, Claudia Borelli, Syrus Karsai, Gerd Kautz, Tanja C. Fischer, Michael Drosner, Stefan Hammes, Konstantin Feise, Christian Raulin, Martina Kerscher, Gerd Gauglitz, Jens M. Baron, Stefan W. Schneider, Katharina Herberger   +16 more
wiley   +1 more source