Results 151 to 160 of about 1,426 (184)

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Implementation strategies for early hand therapy for young children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To select and prioritize implementation strategies for early hand therapy for children under 2 years old with suspected or confirmed cerebral palsy. Method This implementation study used a mixed‐methods sequential explanatory design guided by the Consolidated Framework for Implementation Research.
Alicia J Hilderley, Dejana Nikitovic, Darcy Fehlings, John Andersen, Eleanor Heptonstall, Christine Cassidy, Adam Kirton, The INTERPLAY Study Team   +7 more
wiley   +1 more source

Placebo zones in discontinuity‐based designs: Estimation, inference, and implementation

Economic Inquiry, EarlyView.
Abstract We propose a new model‐selection algorithm for regression discontinuity design and related estimators. The performance of candidate models is assessed within a “placebo zone” of the running variable. Candidate models can differ by bandwidth and other choice parameters.
Nathan Kettlewell, Peter Siminski
wiley   +1 more source

Political Partisanship and State‐Level Bank Efficiency

Financial Review, EarlyView.
ABSTRACT We examine the relationship between political partisanship and commercial bank efficiency in the United States from 1972 to 2020, assessing the persistent influence of political affiliations at the state and District of Columbia levels. Bank efficiency scores are estimated using a double‐bootstrap approach, and the analysis is conducted within
Jeremy Eng‐Tuck Cheah, Tapas Mishra, Sofia Johan, Thao Ngoc Nguyen   +3 more
wiley   +1 more source

From “Striving to Survive” to “Striving to Thrive”: A Narrative Inquiry Into a Student's Motivational Development via Translanguaging in EAP and EMI Contexts

International Journal of Applied Linguistics, EarlyView.
ABSTRACT While English‐medium instruction (EMI) and English for Academic Purposes (EAP) courses are designed to promote language and content learning, their prevailing English‐only approaches often undermine students’ learning motivation. Against this backdrop, translanguaging has gained recognition as an effective pedagogical practice to support ...
Yihai Wen, Fan Fang
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Decisions Under Radical Uncertainty: The Role of Volitional Liminality in Radical Innovation

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Radical innovation management can be understood as an organizational practice that enacts distant futures, which are open‐ended and unknowable. Such radical innovation endeavors are thus characterized by radical uncertainty, where possible futures are not only quantitatively but qualitatively different from the present, and ...
José Antonio Rosa, Marcelo F. de la Cruz Jara, Jelena Spanjol   +2 more
wiley   +1 more source

Artificial Intelligence in Periodontology: A Systematic Review

Journal of Periodontal Research, EarlyView.
AI shows promise across periodontology, with deep learning achieving strong performance for image‐based diagnosis of periodontitis. However, limited data diversity, inconsistent metrics, and scarce external validation raise concerns about generalizability and clinical applicability.
Antonin Tichy, Nils Werner, Helena Dujic, Charlotte Wetzel, Vinay Pitchika, Caspar Victor Bumm, Matthias Folwaczny, Falk Schwendicke   +7 more
wiley   +1 more source