Results 11 to 20 of about 5,571 (156)

慢性HBV感染患者抗原表位特异性CTL与ALT水平无关 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 2006
[目的]通过定量分析慢性乙型肝炎患者体内乙型肝炎病毒（HBV）特异性的细胞毒性T淋巴细胞,探讨特异性细胞毒性T淋巴细胞水平与血清丙氨酸氨基转移酶水平和病毒复制状态的关系.[方法]从慢性乙型肝炎患者外周血分离外周血单个核细胞（PBMC）,用HLA-A2限制的HBcAg抗原表位肽-五聚体复合体及CD8单克隆抗体染色后,用流式细胞仪检测HBV特异性的细胞毒性T淋巴细胞,同时检测患者的肝功能和定量分析HBV DNA.[结果]32例HLA-A2阳性的慢性乙型肝炎患者外周血均可检测到HBV特异性的细胞毒性T淋巴细胞,
邓洪, 韩晓燕, 陈幼明, 张富程, 彭晓谋, 高志良, 姚集鲁   +6 more
doaj   +2 more sources

鼻咽癌细胞培养上清对正常人淋巴细胞钙调蛋白、白细胞介素-2、白细胞介素-2受体活性及T淋巴细胞增殖的影响 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 1991
观察鼻咽癌低分化细胞株(CNE-2)培养上清(CNE-2S)对正常人外周血淋巴细胞(PBL)的作用,结果表明:CNE-2S可明显抑制正常人T淋巴细胞的增殖,白细胞介素-2(IL-2)的产生及钙调蛋白(CaM)的活性。但对IL-2受体活性无明显影响。提示CNE-2S有可能是通过抑制淋巴细胞内CaM的活性,使细胞代谢改变,而阻碍T淋巴细胞增殖。
doaj   +2 more sources

Histopathological characterisation of trunk‐dominant canine pemphigus foliaceus, and comparison with classic facial and insecticide‐triggered forms

Veterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023
Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon, Petra Bizikova, Thierry Olivry, Ekaterina Mendoza‐Kuznetsova, Ursula Oberkirchner, James Benjamin Robertson, Keith Emerson Linder   +6 more
wiley   +1 more source

Stress hyperglycemia ratio is associated with systemic inflammation and clinical outcomes in diabetic inpatients with pneumonia on admission 糖尿病合并肺炎住院患者的应激性高血糖率与全身性炎症和临床结局相关

Journal of Diabetes, Volume 15, Issue 7, Page 545-556, July 2023., 2023
Highlights High stress hyperglycemia ratio (SHR) was associated with elevated systematic inflammation in diabetic inpatients with pneumonia on admission. In the absence of hypoglycemia on admission, SHR was of J‐shaped associations with adverse clinical outcomes in diabetic inpatients with pneumonia of different severity.
Bing Liu, Yu Chen, Liping Yu, Min Zhou
wiley   +1 more source

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes 中性粒细胞计数升高与2型糖尿病患者慢性肾脏病变的发展相关

Journal of Diabetes, Volume 14, Issue 7, Page 442-454, July 2022., 2022
HighlightsNeutrophil count was an independent risk factor for CKD in patients with diabetes, especially when it exceeded 3.6 × 109/L, and increased neutrophil count could predict progression of CKD in patients with diabetes. Abstract Background This study aims to investigate the potential association of peripheral inflammatory blood cell parameters ...
Rui Zhang, Jin Chen, Yanqin Xiong, Lihong Wang, Xinmei Huang, Tiange Sun, Bingbing Zha, Yueyue Wu, Cuili Yan, Shufei Zang, Qin Zhou, Zhe Huang, Jun Liu   +12 more
wiley   +1 more source

Altered plasma cytokines in dogs with atopic dermatitis

Veterinary Dermatology, Volume 33, Issue 2, Page 131-e38, April 2022., 2022
Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier, Linda J. Vogelnest, Rosanne M. Taylor, Peter Williamson   +3 more
wiley   +1 more source

Chinese Clinical Named Entity Recognition with ALBERT and MHA Mechanism

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Traditional clinical named entity recognition methods fail to balance the effectiveness of feature extraction of unstructured text and the complexity of neural network models. We propose a model based on ALBERT and a multihead attention (MHA) mechanism to solve this problem.
Dongmei Li, Jiao Long, Jintao Qu, Xiaoping Zhang, Xuezhong Zhou   +4 more
wiley   +1 more source

Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update

Veterinary Dermatology, Volume 32, Issue 6, Page 579-e156, December 2021., 2021
Culicoides hypersensitivity (CH) is a strongly pruritic dermatitis of horses, characterised histologically by mixed perivascular to diffuse cellular infiltrates of mononuclear cells and eosinophils, and caused by helper T cell (Th)2, immunoglobulin (Ig)E‐mediated reactions to antigens present in the saliva of biting Culicoides midges.
Eliane Marti, Ella N. Novotny, Iva Cvitas, Anja Ziegler, A. Douglas Wilson, Sigurbjörg Torsteinsdottir, Antonia Fettelschoss‐Gabriel, Sigridur Jonsdottir   +7 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

风湿热患者外周血淋巴细胞和血清对心脏细胞的毒性作用 [PDF]

Zhongshan Daxue xuebao. Yixue kexue ban, 1993
用26例风湿热患者外周血淋巴细胞和血清分别加到原代培养的人胚心肌细胞和心肌间质细胞中,观察其对上述两种细胞的毒性作用,结果发现:①风湿性心脏炎患者外周血T淋巴细胞和血清抗心肌抗体对心肌细胞和心肌间质细胞均有毒性作用。②单纯风湿性关节炎患者和风湿性心脏病风湿活动静止期患者外周血T淋巴细胞和血清对心肌细胞和心肌间质细胞无毒性作用。提示体液免疫和细胞免疫均参与风湿性心脏炎的发病机制。
doaj   +2 more sources