Results 141 to 150 of about 2,269,258 (384)

Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.

Journal of Clinical Oncology, 2015
PURPOSE Aurora A kinase (AAK) is upregulated in highly proliferative lymphomas, suggesting its potential as a therapeutic target. Alisertib is a novel oral AAK inhibitor without adverse safety signals in early-phase studies that demonstrated preliminary ...
P. Barr, Hongli Li, C. Spier, D. Mahadevan, M. LeBlanc, Mansoor Ul Haq, Bryan D. Huber, C. Flowers, N. Wagner-Johnston, S. Horwitz, R. Fisher, B. Cheson, Sonali M. Smith, B. Kahl, N. Bartlett, J. Friedberg   +15 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets

Haematologica, 2015
Reliable information regarding the current prevalence of peripheral T-cell lymphoma (PTCL) entities is missing. Herein we report on the frequency of PTCL entities in France between 2010 and 2013. Using Lymphopath , a national lymphoma network established
L. de Leval, M. Parrens, Fabien Le Bras, J. Jais, V. Fataccioli, Antoine Martin, L. Lamant, R. Delarue, F. Berger, F. Arbion, C. Bossard, M. Copin, D. Canioni, F. Charlotte, G. Damaj, P. Dartigues, B. Fabiani, A. Ledoux-Pilon, K. Montagne, T. Molina, M. Patey, Patrick Tas, M. Péoch, B. Petit, T. Petrella, J. Picquenot, T. Rousset, M. Rousselet, I. Soubeyran, S. Thiébault, O. Tournilhac, L. Xerri, C. Gisselbrecht, C. Haioun, G. Delsol, P. Gaulard   +35 more
semanticscholar   +1 more source

NMDAR‐Antibody Encephalitis Diagnosed With Primary Central Nervous System Lymphoma: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT N‐methyl‐D‐aspartate receptor‐antibody encephalitis (NMDAR encephalitis) is one of the most common forms of autoimmune encephalitis, with a paraneoplastic relationship described in approximately 38%. Primary central nervous system lymphoma (PCNSL) is a rare hematologic malignancy that is not often considered as the underlying neoplasm in this ...
Soo Hyun Ahn, Cynthea Prima, Tae Min Kim, Soon‐Tae Lee, Kon Chu   +4 more
wiley   +1 more source

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]

, 1992
Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M, Buck, D, Cayabyab, M, Lanier, LL, Phillips, JH   +4 more
core   +1 more source

Identification of cell-type-specific mutations in nodal T-cell lymphomas [PDF]

, 2017
Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including ...
Asabe Y, Chiba K, Chiba S, Izutsu K, Kano J, Matsubara D, Minowa T, Miyano S, Miyoshi H, Nakamura N, Nguyen T B, Noguchi M, Ogawa S, Ohshima K, Sakata-Yanagimoto M, Shiraishi Y, Takeuchi K, Tanaka H, Yoshida K, 加野 准子, 千葉 滋, 坂田（柳元） 麻実子, 野口 雅之   +22 more
core   +1 more source

Cognitive and Patient‐Reported Outcome Measures in LGI‐1‐IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical outcome measures for autoimmune encephalitis (AE) are not yet well defined. Cognitive outcome measures (CogOs) and patient‐reported outcomes (PROs) may capture the symptoms of AE, beyond clinician‐reported outcomes (ClinROs) (the Modified Rankin Scale [mRS] and Clinical Assessment Scale in Autoimmune Encephalitis [CASE ...
Tatchaporn Ongphichetmetha, Carol Swetlik, Nicolas Thompson, Albert Aboseif, Vineet Punia, Brittany Lapin, Jeffrey A. Cohen, Rachel Galioto, Amy Kunchok   +8 more
wiley   +1 more source

When the mask slips: A peripheral T-cell lymphoma disguised as lupus with myelofibrosis in a patient with May-Hegglin syndrome

Leukemia Research Reports
We describe the case of a female patient with May-Hegglin syndrome who developed peripheral T-cell lymphoma not otherwise specified. The patient presents with systemic lupus erythematous phenotype and myelofibrosis secondary to T-cell lymphoma ...
V Da Silva Constante, H Couvert, A Wolfromm, M Ilzkovitz   +3 more
doaj  

MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells

Molecular Cancer, 2019
Background MicroRNAs (miRs) are involved in lymphoma progression by regulating tumor cell interaction with microenvironment. MiR155 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological effect on tumor microenvironment needs to be ...
Zhong Zheng, Rui Sun, Hui-Jin Zhao, Di Fu, Hui-Juan Zhong, Xiang-Qin Weng, Bin Qu, Yan Zhao, Li Wang, Wei-Li Zhao   +9 more
doaj   +1 more source

Challenging perspectives on the cellular origins of lymphoma. [PDF]

, 2016
Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon
Hodson, Daniel J, Macintyre, Elizabeth A, Malcolm, Tim IM, Turner, Suzanne D   +3 more
core   +2 more sources