PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets [PDF]
, 2006 The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Eckert, Anne +4 more
core
Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients [PDF]
, 2013 PurposeLymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing this recovery are important ...
Bae +23 more
core +1 more source
Oligoclonality of Rat Intestinal Intraepithelial T Lymphocytes: Overlapping TCR β-Chain Repertoires in the CD4 Single-Positive and CD4/CD8 Double-Positive Subsets [PDF]
, 1999 Lars Helgeland +4 more
openalex +1 more source
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2022 ObjectiveTo compare the absolute counts of lymphocyte subsets in patients with chronic kidney disease （CKD）3~5， examine the risk factors related to lymphocyte subsets and elucidate the relationship between renal function and immune homeostasis.MethodsA ...
Huang Yi-jia +5 more
doaj
Prospective Analysis of Stress and Immunity in Advanced Cancer [PDF]
, 2011 Objectives:The aims of this study were to assess chronic stress in a sample of advanced cancer patients, test the association between stress and NK cell immune markers over time, and examine whether stress predicts immune markers over time.Methods:A ...
Ikpeama, Uzoh Erick
core +1 more source
Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]
, 2009 Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
core +1 more source
Experimental immunology<br>Influence of polysaccharide fraction C isolated from <i>Caltha palustris</i> L. on T and B lymphocyte subsets in mice [PDF]
, 2012 Agnieszka Suszko +4 more
openalex +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source