Results 81 to 90 of about 54,569 (261)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

T helper type-1 lymphocytes drive inflammation in human atherosclerotic lesions [PDF]

, 2003
Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti ...
DEL PRETE G., Telford J. L., Antonio Cassone, AZZURRI A, Cassone, A., DELIOS M. M, John L. Telford, Romagnani, Sergio, CIERVO A, Tamburini, C., Azzurri, A., Amedei, A., AMEDEI A, Carlo Tamburini, Mario M. D'Elios, Ciervo, A., Baldari, C., Benagiano, M., TAMBUTINI C, BALDARI C. T, Annalisa Azzurri, D'Elios, Mario Milco, D'Elios, M. M., TELFORD J. L, Gianfranco Del Prete, Ferrari, M., Amedeo Amedei, ROMAGNANI S, Marisa Benagiano, CASSONE A, Del Prete, Gianfranco, Sergio Romagnani, Del prete, G., Romagnani, S., Mauro Ferrari, BENAGIANO M, Alessandra Ciervo, Cosima T. Baldari, Amedei, Amedeo, FERRARI, MAURO   +39 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Clinical characteristics and expression of Th1-Th2 cytokines in the cerebrospinal fluid of patients with cryptococcal meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Background Cryptococcal meningitis (CM) is the most common fungal infection of central nervous system, caused by Cryptococcus neoformans infection of the meninges. The development and prognosis of CM depend on the patient's own immune function to some
Hui BU, Yun-can WANG, Wen-ting DING, Jun-ying HE, Yue ZHAO, Wen-jing LÜ   +5 more
doaj  

The diagram of the designed MEV construct composed of helper T lymphocytes (HTL), B cell (BCL), cytotoxic T lymphocytes (CTL) epitopes and adjuvant joined together using proper linkers.

, 2023
The diagram of the designed MEV construct composed of helper T lymphocytes (HTL), B cell (BCL), cytotoxic T lymphocytes (CTL) epitopes and adjuvant joined together using proper linkers.
Javad Zamani Amirzakaria (15419294), Shirin Mahmoodi (15419291), Abdolmajid Ghasemian (13531687)   +2 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

, 1998
Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Venaille, T.J., Lee, P.T., Stumbles, P.A., Pimm, C.L., Proksch, S., Holt, P.G., Thomas, J.A.   +6 more
core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Etude de l'interaction entre les mastocytes et les lymphocytes T helper

, 2012
Les mastocytes ont longtemps été associés aux réponses allergiques, néanmoins de nombreuses études les décrivent comme des acteurs de la réponse inflammatoire.
Gaudenzio, Nicolas
core