Results 111 to 120 of about 132,088 (293)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Novel Aczel-Alsina Power Aggregation Operators for Circular Pythagorean Fuzzy Linguistics With Application to Waste Reduction and Recycling in Green Supply Chain Management

IEEE Access
The model of Aczel-Alsina t-norm and Aczel-Alsina t-conorm is very flexible because of the involvement of a free parameter, where the algebraic norms and Drastic norms are the special cases of the Aczel-Alsina norms.
Zeeshan Ali, Mehboob Ali, Shi Yin, Miin-Shen Yang   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Definition of Triangular Norms and Triangular Conorms on Subfamilies of Type-2 Fuzzy Sets

Axioms
In certain stages of the application of a type-2 fuzzy logic system, it is necessary to perform operations between input or output fuzzy variables in order to compute the union, intersection, aggregation, complement, and so forth.
Pablo Hernández-Varela, Francisco Javier Talavera, Susana Cubillo, Carmen Torres-Blanc, Jorge Elorza   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assertiveness Skills Training Efficiency on College Students’ Persuasive Subjective Norms against Substance Abuse

پزشکی بالینی ابن سینا, 2011
Introduction & Objective: The prevalence of substance abuse among college students is increasing drastically and requires immediate skill-based substance abuse intervention such as assertive skills.
Majid Barati, Hamid Allahverdipour, Babak Moeini, Abdallah Farhadi Nasab, Hosein Mahjub, Farzad Jalilian   +5 more
doaj  

The Influence of Personal Norms and Tax Compliance Intentions on The Tax Compliance Behavior of MSME Actors

Jurnal Aplikasi Bisnis dan Manajemen
Background: MSMEs dominate the Indonesian economy. The growth of MSMEs shows that the number of MSMEs is quite large and continues to increase every year, thus indicating that MSMEs may be able to generate tax revenue.
Aprih Santoso, Susanto, R. Dwi Widi Pratito, Vensy Vydia, Cristino Gusmao   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Approach for Full Reinforcement-Based Biometric Score Fusion

IEEE Access
Multibiometric systems have the potential to mitigate error rates and address certain inherent weaknesses found in unimodal systems. This study introduces an innovative scheme for user recognition in multibiometric systems, centered on a score-level ...
Mohamed Cheniti, Zahid Akhtar, Chandranath Adak, Kamran Siddique   +3 more
doaj   +1 more source