Results 261 to 270 of about 11,150,608 (308)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Enhancing cropping intensity and system productivity through early-bulking potato genotypes in potato-based cropping systems. [PDF]

PLoS One
Hossain MM, Islam AKMM, Tasnim J, Sarkar MAR, Barma NCD, Hasan AK.   +5 more
europepmc   +1 more source

Impaired sleep resilience underlies transient neural instability in insomnia disorder. [PDF]

iScience
Yang C, Gu H, Chen H, Chen G, Song X, Liu X, Yang Q, Wang G, Li C, Gu H, Wang S, Guo P, Zhao J, Wang L, Wang R, Wang C, Mei J, Li X.   +17 more
europepmc   +1 more source

Hierarchical recurrent temporal prediction as a model of the mammalian dorsal visual pathway. [PDF]

PLoS Comput Biol
Klavinskis-Whiting S, King AJ, Harper NS.   +2 more
europepmc   +1 more source

Sample Size Determination for Comparing Slopes in Cluster Randomized Trials With Longitudinal Measurements. [PDF]

Stat Med
Wang J, Zhang S, Ahn C.
europepmc   +1 more source

A Bayesian network approach to evaluating footwear evidence. [PDF]

Forensic Sci Int Synerg
Kellett D, Lagnado D, Morgan R, Nakhaeizadeh S.   +3 more
europepmc   +1 more source

Impact of intrauterine infusion of human umbilical cord blood mononuclear cells on reproductive outcomes in patients with thin endometrium undergoing frozen embryo transfer. [PDF]

Front Cell Dev Biol
Xing R, Hao GM, Wu YJ, Zuo XQ, Zhao P, Mi CH, Yang CP, Jia K, Yang AM.   +8 more
europepmc   +1 more source

Application of multivariate T-pattern analysis in the study of social interaction in rats

, 2015
Casarrubea, M, Cardaci, M, Sorbera, F, Faulisi, F, Crescimanno, G   +4 more
openaire   +1 more source