Results 41 to 50 of about 719,719 (259)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Comparisons of Two Bioelectrical Impedance Devices and Manual versus Sensor-Based Short Physical Performance Batteries for Assessment of Muscle Mass and Physical Performance

Sensors, 2023
The assessment of muscle mass and physical performance is essential for the diagnosis of sarcopenia. This study examined the validity of bioimpedance analysis (BIA) and a sensor-based short physical performance battery (SPPB) device for analyzing ...
Jin-Young Min, Kyoung-Bok Min
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Top quark mass measurements at the $$t\bar{t}$$ t t ¯ threshold with CEPC

European Physical Journal C: Particles and Fields, 2023
We present a study of top quark mass measurements at the $$t\bar{t}$$ t t ¯ threshold based on CEPC. A centre-of-mass energy scan near two times of the top quark mass is performed and the measurement precision of top quark mass, width and $$\alpha _S$$ α
Zhan Li, Xiaohu Sun, Yaquan Fang, Gang Li, Shuiting Xin, Shudong Wang, Yiwei Wang, Yuan Zhang, Hao Zhang, Zhijun Liang   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

T-SCAN sustav za elektroničku analizu okluzije [PDF]

Sonda : List studenata Stomatološkog fakulteta Sveučilišta u Zagrebu, 2011
T - Scan je sustav za kvantitativnu analizu zubnih dodira koji omogućava bilježenje redoslijeda, rasporeda, vremena trajanja i relativne jakosti sila zubnih dodira.Klinički rad s T-Scan sustavom je jednostavan i pouzdan te zbog preciznosti u snimanju zubnih dodira taj sustav predstavlja veliki potencijal u dijagnozi i terapiji poremećaja okluzije.
Rupić, Ivana, Rukavina, Marina, Dulčić, Nikša   +2 more
openaire   +4 more sources

A T-Scan Analysis of Bite Force Distribution in Natural Dentition – A Prospective Study

Indian Journal of Dental Research
Aim: The aim of this study is to investigate the distribution of bite force within arches in natural dentition. Methodology: A cohort of (number) participants with intact permanent dentition was recruited for this cross-sectional study. T-Scan technology,
K. Lokesh Sai, Keerthi Sasanka, Nadhirah Faiz, Varun Keskar, Divyansh Sinha   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source