Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Health-related quality of life and mental health in patients with major bone and joint infections
Bone & Joint OpenAims: It is well described that patients with bone and joint infections (BJIs) commonly experience significant functional impairment and disability. Published literature is lacking on the impact of BJIs on mental health. Therefore, the aim of this study
Katinka Wetzel +4 more
doaj +1 more source
Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system. [PDF]
RSC Adv, 2023 El Khoury R +3 more
europepmc +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
IMPROVING STUDENTS LISTENING COMPREHENSION AT SMKN 1 TANAH GROGOT EAST KALIMANTAN USING DICTOGLOSS STRATEGY [PDF]
The research aims to determine whether the dictogloss strategy improves listening comprehension at SMKN 1 Tanah Grogot or not. The design of this research is quasi-experimental. The population of this research was the students of SMK N 1 Tanah Grogot and
Hasanna, Salsabilla Kirananda
core
Testing Internal Quality Control of Clinical Laboratory Data Using Paired t-Test under Uncertainty. [PDF]
Biomed Res Int, 2021 Albassam M, Aslam M.
europepmc +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
KARAKTERISASI 5 KANDIDAT VARIETAS F1 TANAMAN BUNGA KOL (Brassica oleracea L. var. botrytis) DI DATARAN RENDAH [PDF]
Cauliflower (Brassicca oleracea var. botrytis) is one of the commercially valuable vegetables with high demand for domestic food supply. Efforts to enhance plant production can be undertaken through a plant breeding program. The initial step involves the
Ardi, Intan Anggraini Putri
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source