Results 251 to 260 of about 29,531,512 (317)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comprehensive tumour-immune profiling reveals TREM2⁺ tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma. [PDF]

Clin Transl Med
Wu Z, Cheng C, Li Z, Ren M, Cao H, Huang W, Wang J, Wu L, Lee T, Zhang S, Zheng H, Wang Y.   +11 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling T_H2 to T_H17 cell conversion via interleukin-4-STAT5 axis in mice. [PDF]

Nat Commun
Zhao M, Zhang C, Zhang X, Mu Q, Li Q, Liu YC.   +5 more
europepmc   +1 more source

The Devil Is in the Tail: Manchester Short Assessment of Quality of Life (MANSA) test percentiles and normalized T-scores. [PDF]

J Psychopathol Behav Assess
de Beurs E, Jeronimus BF.
europepmc   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy. [PDF]

CNS Neurosci Ther
Zhou Z, Yu X, Tian E, Guo Z, Chen J, Guo J, Shi S, Xu W, Zhai N, Qiao C, Zhang Y, Wang J, Lu Y, Zhang S.   +13 more
europepmc   +1 more source

When Familiar Faces Feel Better: A Framework for Social Neurocognitive Aging in a Rat Model. [PDF]

eNeuro
Dutta Gupta S, Long JM, Rapp PR.
europepmc   +1 more source

Children's Numerical Estimation Is Biased by Male Informants More Than Female Informants. [PDF]

Dev Sci
Cracknell K, Hauss J, Chen M, Sierp R, Bian L, Wang J.   +5 more
europepmc   +1 more source