Results 161 to 170 of about 37,328 (178)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Evaluating PREPaRe (Promoting Readiness and Engagement in Pain Rehabilitation): A Randomized Controlled Trial of a Telehealth Motivational Interviewing Intervention for Youth and Families With Chronic Pain. [PDF]

Clin J Pain
Smith AM, Rogan H, Logan DE.
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Association Between the Lactate-to-Albumin Ratio and ICU/In-Hospital Mortality in Critically Ill Patients With Comorbid Type 2 Diabetes Mellitus : A Cohort Study Utilizing the MIMIC-IV Database. [PDF]

Emerg Med Int
Cheng ZT, Wang JL, Zhao YB, Zhao ZM, Li ZJ, Liu Y.   +5 more
europepmc   +1 more source

Knitted Pneumatic Fabrics for Dynamic Pressure Modulation in Personalized Healthcare Wearables

Advanced Science, EarlyView.
A pneumatic pressure‐regulating knitted fabric (PPKF) is developed, in which knitted pneumatic circuit enables the seamless integration of ultralow radial expansion pneumatic fiber into dual‐channel textile structure. By strategically modulating channel spacing, delivering adjustable dynamic pressures and clinically relevant gradient compression ratios.
Xiaoyu Chen, Jintu Fan, Rong Zheng, Qing Chen, Fengxin Sun, Huanhuan Liu   +5 more
wiley   +1 more source

ECG-Guided Antiarrhythmic Therapy in Acute Coronary Syndrome: A Multidimensional Assessment of Biomarkers, Cardiac Function, and Quality of Life. [PDF]

Ther Clin Risk Manag
Li X, Liu X, Jing M, Yang C, Luo H, Li L.   +5 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Impact of Oral Hygiene Instructions in the Resolution of Peri-Implant Mucositis. A Randomized Controlled Trial. [PDF]

Clin Oral Implants Res
de Tapia B, Babiano Á, Oreglia MV, Valles C, Nart J.   +4 more
europepmc   +1 more source

Bioenergy Cropping Reduces the Spatiotemporal Scaling of Soil Bacterial Biodiversity

Advanced Science, EarlyView.
Consistent with patterns observed in plant and animal communities, soil bacterial communities exhibit significant species–time–area and phylogenetic–time–area relationships independent of nested structure. Bioenergy cropping significantly reduces the spatiotemporal scaling rates, particularly in sandy loam soils.
Zhencheng Ye, Jialiang Kuang, Colin T. Bates, Arthur Escalas, Daliang Ning, Liyou Wu, Suo Liu, Sihang Deng, Jiesi Lei, Xiangwen Chen, Jennifer Pett‐Ridge, Malay Saha, Lauren Hale, Gangsheng Wang, Renmao Tian, Ying Fu, Yu Tang, Mary Firestone, Jizhong Zhou, Yunfeng Yang   +19 more
wiley   +1 more source