Results 271 to 280 of about 13,979,009 (326)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Results of Welch’s individual t-test comparing differences in normalized shell dissolution between valves abraded with sandpaper (fine or coarse grit), and normalized CaCO₃ dissolution in unabraded control valves also lacking periostracum^†.

Alisha M. Saley (21728455), Aaron T. Ninokawa (3309963), Abigail Doan (21728458), Brian Gaylord (591291)   +3 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Taurine and betaine promote lactate clearance in canine hepatocytes by enhancing gluconeogenesis. [PDF]

Front Vet Sci
Ma Y, Li J, Li Y, Lv L.
europepmc   +1 more source

Relation between socio-demographic characteristics and mean HAM – A scores for anxiety (using independent sample t – test).

Mohammad Sabeeh Ul Haq (21402663), Dua Nilofar Jawed (21402666), Nehrish Patel (21402669), Waqar Khan (4731414), Aisha Alamgir (21402672), Shagufta Yamin (21402675), Rabia Anwar (21402678), Tafazzul Hyder Zaidi (21402681), Munawar Khursheed (6523670)   +8 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Statin prescription patterns among patients with type 2 diabetes mellitus for primary and secondary prevention of cardiovascular disease. [PDF]

BMC Endocr Disord
Abdelaal AM, Ghonem M, Mohamed YA, Hasan AS, Kyrillos F.   +4 more
europepmc   +1 more source

T-test results for the effect of HF conversation on SDLP across different traffic conditions. Significant differences are indicated by p < 0.05.

Mobina Faqani (22783963), Habibollah Nassiri (13977637), Mahdi Rezaei (22783966), Mohsen Ramezani (4966906)   +3 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer. [PDF]

Signal Transduct Target Ther
Guo X, Liu Y, Li T, An X, Song Y, Xu P, Huang J, Zou Y, Xu B, Xie Y, Li Z, Meng C, Zhao T, Wang X, Wang H, Gao C, Zhou X, Yu J, Gao S, Hao J.   +19 more
europepmc   +1 more source