Results 11 to 20 of about 41,287 (111)

Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712

, 2023
Tyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase that belongs to the JAK family also comprising JAK1, JAK2, and JAK3. TYK2 is an attractive target for various autoimmune diseases as it regulates signal transduction downstream of IL-23 and IL-12 ...
Jeremy Edmunds (17137385), Ellen Chien (17137370), J. Martin Herold (1330506), Matthew P. Webster (1335339), Marlon Cowart (2668408), Dawn Bennett (5297042), Julie Parmentier (5688911), Andrew Little (2078797), Wei Qiu (217045), Michael Friedman (559689), Candace Graff (5688914), Theresa Dunstan (17137376), Matthew Perham (5544311), David Hardee (17137379), Richard McCarthy (16139993), Stacy Van Epps (17137367), Michael Schrimpf (7592432), Eric Breinlinger (2983149), Fei Wu (117860), Gekleng Chhor (17137373), Maria Argiriadi (1692694), Thomas Vargo (17137382)   +21 more
core   +2 more sources

Biography and History [712]

, 2021
Biography and History. This manuscript is now IO Islamic 3016 in the India Office collections. [metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no.
Anon
core   +1 more source

ADC 712

, 2009
onderzoeksrappor
Sophie, G.
core   +1 more source

High-precision segmentation and quantification of tunnel lining crack using an improved DeepLabV3+

Underground Space
Current semantic segmentation models have limitations in addressing tunnel lining crack, such as high complexity, misidentification, or inability to detect tiny cracks in specific practical scenarios, which is crucial for precise assessment of tunnel ...
Zhutian Pan, Xuepeng Zhang, Yujing Jiang, Bo Li, Naser Golsanami, Hang Su, Yue Cai   +6 more
doaj   +1 more source

A state‐of‐the‐art review on geothermal energy exploration in Morocco: Current status and prospects

Deep Underground Science and Engineering
In the last few decades, addressing the global challenge of implementation of strategies for renewable energy and energy efficiency has become crucial.
Redouane Meryem, Khalis Hind, Haissen Faouziya, Sadki Othman, Berkat N. Eddine, Raji Mohammed   +5 more
doaj   +1 more source

Reliable prediction for TBM energy consumption during tunnel excavation: A novel technique balancing explainability and performance

Underground Space
Recently, AI-based models have been applied to accurately estimate tunnel boring machine (TBM) energy consumption. Although data-driven models exhibit strong predictive capabilities, their outputs derived from “black box” processes are challenging to ...
Wenli Liu, Yafei Qi, Fenghua Liu
doaj   +1 more source

Effect of constructing twin tunnels under a building supported by pile foundations in the Sydney central business district

Underground Space, 2019
In congested cities such as Sydney, competition for underground space escalates within the built environment because various assets require finite geotechnical strength and support. Specific problems such as damage to buildings may develop when high-rise
Hadi Khabbaz, Robert Gibson, Behzad Fatahi   +2 more
doaj   +1 more source

Particle crushing and critical state surface of porous granular materials derived from artificial pumice

Soils and Foundations
Crushable porous soils, such as volcanic pumice, are distributed worldwide and cause a variety of engineering problems, such as slope hazards. The mechanical properties of these soils are complicated by their high compressibility due to voids in the ...
Itsuki Sato, Reiko Kuwano, Masahide Otsubo   +2 more
doaj   +1 more source

Effect of pore water chemistry on anisotropic behavior of clayey soil and possible application in underground construction

Underground Space, 2016
The effect of pore water chemistry on anisotropic behavior of consolidation and shear strength of reconstituted Ariake clay has been investigated experimentally.
Jinchun Chai, Takehito Negami, Kosuke Aiga, Takenori Hino   +3 more
doaj   +1 more source

Long-term response of flexible pipe in sand trench due to consolidation of native clay

Soils and Foundations, 2021
The finite element analysis are performed to investigate a long-term response of flexible pipe buried in sand trench embedded in native soft clay. The investigated long-term behaviors are due to effects of backfill soil structure rearrangement and native
S. Yimsiri, W. Ratananikom
doaj   +1 more source