Results 151 to 160 of about 7,324,140 (348)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Prioritizing Technical Debt in Database Normalization Using Portfolio Theory and Data Quality Metrics [PDF]

open access: yesarXiv, 2018
Database normalization is the one of main principles for designing relational databases. The benefits of normalization can be observed through improving data quality and performance, among the other qualities. We explore a new context of technical debt manifestation, which is linked to ill-normalized databases.
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Syntagma Lexical Database [PDF]

open access: yesarXiv, 2015
This paper discusses the structure of Syntagma's Lexical Database (focused on Italian). The basic database consists in four tables. Table Forms contains word inflections, used by the POS-tagger for the identification of input-words. Forms is related to Lemma.
arxiv  

Design and implementation of a database for the estimation of environmental indicators in an input—output framework with the use of NAMEA tables [PDF]

open access: bronze, 2006
Athena Belegri‐Roboli   +5 more
openalex   +1 more source

The ExoMolOP database: Cross sections andk-tables for molecules of interest in high-temperature exoplanet atmospheres [PDF]

open access: bronze, 2020
K. L. Chubb   +9 more
openalex   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

NewSQL: Towards Next-Generation Scalable RDBMS for Online Transaction Processing (OLTP) for Big Data Management [PDF]

open access: yesarXiv, 2014
One of the key advances in resolving the big-data problem has been the emergence of an alternative database technology. Today, classic RDBMS are complemented by a rich set of alternative Data Management Systems (DMS) specially designed to handle the volume, variety, velocity and variability ofBig Data collections; these DMS include NoSQL, NewSQL and ...
arxiv  

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