Results 171 to 180 of about 509,994 (339)

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang   +9 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li   +9 more
wiley   +1 more source

Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder. [PDF]

open access: yesPharmaceutics
Horváth ZM   +6 more
europepmc   +1 more source

Controlled Magnesium Ion Delivery via Mg‐Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a controllable degradation system for Mg‐based biomaterials using sputtering technology, marking a significant advancement in nerve regeneration research. The Mg‐sputtered nerve conduits demonstrate enhanced biocompatibility, biofunctionality, mechanical compatibility, and precise magnesium release, resulting in improved axonal ...
Hyewon Kim   +12 more
wiley   +1 more source

Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures

open access: yesAdvanced Healthcare Materials, EarlyView.
SiNW mat‐based MEA (NW_MEA) enables continuous intracellular recordings from neurons in primary rat DRG cell cultures, identifying C‐fiber nociceptors. Supported by an astrocyte feeder layer, SiNW mat promotes DRG neuron and glial cell growth, preserving in vivo‐like cell characteristics and allowing drug‐modulated activity monitoring.
Ivano Lucarini   +12 more
wiley   +1 more source

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