Results 91 to 100 of about 125,081 (296)

LES of Premixed Turbulent Combustion Using Filtered Tabulated Chemistry

Flow, Turbulence and Combustion
AbstractThe filtered tabulated chemistry (FTACLES) approach utilizes data from pre-tabulated explicitly filtered 1D flame profiles for closure of the LES-filtered transport terms. Different methodologies are discussed to obtain a suitable progress variable c from detailed chemistry calculations of a methane/air flame.
Maximilian Bambauer, Michael Pfitzner, Markus Klein   +2 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Implementation of solar UV and energetic particle precipitation within the LINOZ scheme in ICON-ART [PDF]

Geoscientific Model Development
We extended the Linearized ozone scheme – LINOZ in the ICON (ICOsahedral Nonhydrostatic) – ART (the extension for Aerosols and Reactive Trace gases) model system to include NOy formed by auroral and medium-energy electrons in the upper mesosphere and ...
M. Ramezani Ziarani, M. Ramezani Ziarani, M. Sinnhuber, T. Reddmann, B. Funke, S. Bender, M. Prather   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mapping Machine Learning Trends in Chemistry Research using LLM with Multi-Turn Prompting

Sistemasi: Jurnal Sistem Informasi
A review of research in the field of chemistry that incorporates machine learning is essential to identify recent developments and explore its potential applications. Published research articles provide an opportunity to analyze emerging research trends.
Andreo Yudertha, Riski Dwimalida Putri
doaj   +1 more source

Numerical investigation of a helicopter combustion chamber using LES and tabulated chemistry

Comptes Rendus. Mécanique, 2013
This article presents Large Eddy Simulations (LES) of a realistic aeronautical combustor device: the chamber CTA1 designed by TURBOMECA. Under nominal operating conditions, experiments show hot spots observed on the combustor walls, in the vicinity of the injectors.
Auzillon, Pierre, Riber, Eleonore, Gicquel, Laurent Y.M., Gicquel, Olivier, Darabiha, Nasser, Veynante, Denis, Fiorina, Benoit   +6 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Modelling CO formation in the turbulent interstellar medium

, 2009
We present results from high-resolution three-dimensional simulations of turbulent interstellar gas that self-consistently follow its coupled thermal, chemical and dynamical evolution, with a particular focus on the formation and destruction of H2 and CO.
Abel, Abel, Abrahamsson, Adams, Adams, Adams, Adams, Adams, Aldrovandi, Alge, Andreazza, Anicich, Anicich, Azatyan, Bakes, Ballesteros-Paredes, Ballesteros-Paredes, Ballesteros-Paredes, Balsara, Banerjee, Barinovs, Baulch, Bell, Bergin, Bergin, Bethell, Black, Boisse, Brown, Burton, C. Federrath, Carty, Cen, Chièze, Cohen, Cohen, Colella, Croft, Dalgarno, de Jong, Dean, Dobbs, Dobbs, Dobbs, Dove, Draine, Draine, Dunn, Elmegreen, Fairbairn, Faure, Federer, Federrath, Federrath, Federrath, Federrath, Fehsenfeld, Ferland, Ferrière, Field, Flower, Frank, Frank, Frank, Geppert, Gerlich, Gierens, Glover, Glover, Glover, Goldsmith, Goldsmith, Goldsmith, Gredel, Gredel, Guberman, Habing, Harding, Hayes, Heitsch, Hennebelle, Hennebelle, Hennebelle, Hennebelle, Herbst, Hollenbach, Hollenbach, Hollenbach, Hummer, Janev, Jensen, Johnson, Jones, Karpas, Keenan, Kim, Kim, Kimura, Kimura, Klessen, Klessen, Klessen, Koyama, Koyama, Kramer, Kritsuk, Kritsuk, Krumholz, Lada, Larrouturou, Larson, Larson, Larsson, Launay, Le Bourlot, Le Teuff, Lee, Lee, Lemaster, Lepp, Li, Linder, M.-M. Mac Low, Mac Low, Mac Low, Mac Low, Mac Low, MacGregor, Maloney, Martin, Mauclaire, Mauclaire, McCall, McEwan, McKee, Meijerink, Meyer, Milligan, Mitchell, Mitchell, Murrell, Nahar, Nahar, Natarajan, Nelson, Neufeld, Neufeld, Nordlund, Norman, Oldenborg, Orel, Ostriker, Padoan, Padoan, Pagani, Papadopoulos, Passot, Pavlovski, Peart, Pequignot, Pequignot, Petuchowski, Plewa, Plume, Poulaert, Prasad, R. S. Klessen, Raksit, Ramaker, Roberge, Rosén, Rosén, Roueff, S. C. O. Glover, Savin, Scalo, Schmidt, Schneider, Schroder, Sembach, Shapiro, Shu, Sidhu, Silva, Singh, Slack, Slyz, Smith, Smith, Smith, Smith, Smith, Smith, Stancil, Stancil, Stancil, Sternberg, Stibbe, Stone, Stone, Stutzki, Sun, Sutherland, Takagi, Tsang, van Dishoeck, van Dishoeck, van Dishoeck, van Dishoeck, van Dishoeck, van Leer, Vasyunin, Verner, Viggiano, Voronov, Wagner-Redeker, Wakelam, Walkauskas, Warnatz, Watson, Williams, Wilson, Wishart, Wolfire, Woodall, Xie, Zhao, Zuckerman, Zygelman   +228 more
core   +1 more source