Results 101 to 110 of about 4,618 (156)

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

In Vitro Evaluation of Sugar-Conjugated Thienopyrimidinone Derivatives with Possible Neuroprotective and Antioxidant Effects. [PDF]

Int J Mol Sci
Alshamari AK, Aboulthana WM, Mansour H, Abu-Zied KM, Alshammari OAO, Morsy NM, Alsaif NOS, Alshammari MZ, Nossier ES, Hassan NA.   +9 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Everolimus Mitigates the Risk of Hepatocellular Carcinoma Recurrence after Liver Transplantation. [PDF]

Cancers (Basel)
De Simone P, Precisi A, Lai Q, Ducci J, Campani D, Marchetti P, Gitto S.   +6 more
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

How to assess antioxidant activity? Advances, limitations, and applications of in vitro, in vivo, and ex vivo approaches. [PDF]

Food Prod Process Nutr
Shahidi F, Samarasinghe A.
europepmc   +1 more source

Early Microbiological and Immunological Parameters in Sandblasted, Large‐Grit Acid‐Etched Implant Surfaces: A Split Mouth Randomized Clinical Trial

Clinical Oral Implants Research, EarlyView.
ABSTRACT Aim To compare microbiological and immunological parameters of two sandblasted, large‐grit, acid‐etched implant surfaces during the first 8 weeks of healing following implant placement. Materials and Methods A dual‐center, split‐mouth, randomized controlled clinical trial was conducted on patients receiving one test (modified hydrophilic ...
Blanca Vílchez, Leticia Caneiro, Cristina Lima, Leire Virto, María José Marín, Enrique Bravo, Cristina Chamorro, Ignacio Sanz‐Sánchez, Eduardo Montero, Elena Figuero, Juan Blanco, Mariano Sanz   +11 more
wiley   +1 more source

Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond. [PDF]

Cell Mol Immunol
Yu L, Liu Y, Lin X.
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver. [PDF]

Mol Ther Methods Clin Dev
Gan C, Leng M, Liu Y, Zheng Z, He S, Qiao W, Xiao L, Xiao Y, Ye J, Zhou L, Zhou J, Xiao B, Zhao W, Yang J, Wu A, Zhang H, Hu H, Cen X, Qian Z, Dong H, Valencia CA, Dai L, Chow HY, Zhang L, Dong B.   +24 more
europepmc   +1 more source