Results 101 to 110 of about 14,793,566 (190)

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

Phytotherapy Research, EarlyView.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao, Da Ke, Jian Ni, Yuan Yuan, Zhang Nan, Xiujun Dai, Heng Zhou   +6 more
wiley   +1 more source

A Computational Analysis of Diagnostic Misrecognition in Co-Occurring Primary Headache Disorders: Prime Encoding of ICHD3 Criteria Reveals 72 Potentially Spurious Diagnoses. [PDF]

Diagnostics (Basel)
Zhang P.
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Guazuma ulmifolia butanol extract protects against cadmium-induced hepatotoxicity via HO-1/Sirt-1 activation, miRNA-lncRNA modulation, and metabolic reprogramming. [PDF]

PLoS One
Elsabagh OA, Elgamal AM, Hassan HA, Ammar NM, El-Gendy ZA, El-Saied MA, Ali MM, Ibrahim RS, El-Desoky AH, Hassan EM, Farag MA, Elshamy AI.   +11 more
europepmc   +1 more source

Butein Attenuates Cardiac Hypertrophy by Restoring Redox–Mitochondrial Homeostasis Through Nrf2–Sirt3 Signaling

Phytotherapy Research, EarlyView.
Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley   +1 more source

Real-world treatments and outcomes of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a Japanese claims analysis. [PDF]

Int J Hematol
Shindo T, Shindo M.
europepmc   +1 more source

Tumor microenvironment responsive and nanozyme‐catalyzed photodynamic therapy via lysosome‐localized copper‐doped carbon dots

Responsive Materials, EarlyView.
The lysosome‐localized copper‐doped carbon dots (Cu‐MLCDs) leverage the high expression of glutathione (GSH)/H2O2 in the tumor microenvironment to achieve fluorescence reactivation enhancement. Through its multi‐nanozyme activities (glutathione peroxidase, peroxidase, and catalase), this nanoplatform relieves hypoxia, depletes GSH, and synergistically ...
Weixia Qin, Chengwei Hu, Haimei Zhu, Junjie Cui, Yaqing Cheng, Junfa Zhu, Qian Xu, Antonio Claudio Tedesco, Hong Bi   +8 more
wiley   +1 more source

Oxidative Stress, Pro-Inflammatory Response, Cytotoxicity and Apoptosis Induced by Contemporary Endodontic Sealers in Human Periodontal Ligament Fibroblasts. [PDF]

J Funct Biomater
Krokosz S, Lis VE, Zięba S, Maciejczyk M, Zalewska E, Obrycka M, Gołaś E, Żendzian-Piotrowska M, Ładny J, Skutnik-Radziszewska A, Dąbrowski K, Kuźmiuk J, Zalewska A.   +12 more
europepmc   +1 more source

Widespread Bomb Fishing in Indo‐Pacific Archipelago Revealed Through Machine Learning Accelerated Passive Acoustic Monitoring

Remote Sensing in Ecology and Conservation, EarlyView.
AI‐accelerated passive acoustic monitoring reveals extensive bomb fishing within the Spermonde Archipelago, with annual incidents numbering in the thousands. ABSTRACT Bomb fishing is recognised as the most destructive fishing practice that can be performed in our oceans.
Ben Williams, Mars Coral Restoration Project Monitoring Team, Aimee du Luart, Sonny Burniston, Tries B. Razak, Timothy A. C. Lamont, David J. Smith, Jamaluddin Jompa, David Curnick, Kate E. Jones   +9 more
wiley   +1 more source

Neutral impact of mTOR inhibitors on cardiovascular outcomes after kidney transplantation. [PDF]

Clin Kidney J
Domingo-Pinent E, Cacho J, Cassia M, Torres V, Vergara H, Herceda A, Juarez P, Gonzalez-Rojas Á, Rodríguez-Espinosa D, Montagud-Marrahi E, Arana C, Molina-Andujar A, Ventura-Aguiar P, Esforzado N, Revuelta I, Torregrosa JV, Oppenheimer F, Francino A, Diekmann F, Cucchiari D.   +19 more
europepmc   +1 more source