Results 51 to 60 of about 123,486 (200)

Ti3C2Tx MXene‐Zirconium Diboride Based Ultra‐High Temperature Ceramics

Advanced Science, EarlyView.
This study demonstrates the effectiveness of Ti3C2Tx MXenes as additives in ultra‐high‐temperature ceramics (ZrB₂), enhancing densification, reducing oxygen content, and improving mechanical properties. Through surfactant‐free electrostatic self‐assembly and spark plasma sintering, MXenes enabled the formation of a core–shell microstructure, resulting ...
Srinivasa Kartik Nemani, Nicola Gilli, Steven Goldy, Ankit Kumar, Yooran Im, Austin J. Vorhees, Brian C. Wyatt, Nithin Chandran BS, Nikhilesh Chawla, Garritt J. Tucker, Laura Silvestroni, Babak Anasori   +11 more
wiley   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting

npj Genomic Medicine, 2018
Targeted next-generation sequencing (NGS) methods have become essential in medical research and diagnostics. In addition to NGS sensitivity and high-throughput capacity, precise biomolecule counting based on unique molecular identifier (UMI) has ...
H. Teder, Mariann Koel, P. Paluoja, Tatjana Jatsenko, Kadri Rekker, T. Laisk-Podar, Viktorija Kukuskina, A. Velthut-Meikas, Olga Fjodorova, M. Peters, J. Kere, A. Salumets, P. Palta, K. Krjutškov   +13 more
semanticscholar   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

The Autism–Tics, ADHD and other Comorbidities inventory (A-TAC): previous and predictive validity

BMC Psychiatry, 2017
BackgroundReliable and easy to administer screening instruments focusing on neurodevelopmental disorders and associated conditions are scarce. The Autism–Tics, AD/HD and other Comorbidities inventory (A-TAC) has previously been validated and reporting ...
Caroline Mårland, P. Lichtenstein, A. Degl’Innocenti, T. Larson, M. Råstam, H. Anckarsäter, C. Gillberg, T. Nilsson, S. Lundström   +8 more
semanticscholar   +1 more source

Twin Toughening‐Driven Martensitic Transformation Strategy Synergistic Improvement for Plasticity‐Thermal Shock Resistance of (Hf─Zr─Ti)C Ceramic Coating in Severe Thermal Environments

Advanced Science, EarlyView.
A “ceramic self‐toughening strategy” is introduced for enhancing the plasticity and thermal shock resistance of (Hf─Zr─Ti)C coatings through twin toughening‐driven martensitic transformations in oxide scales. It facilitated the formation of stable, dense, and high‐toughness oxide scales after repeat ablation, and endowed prepared coatings with superior
Jiachen Li, Yulei Zhang, Yanqin Fu, Tao Li, Jian Zhang, Deyu Yang, Lingfei Cao, Fanyu Lu, Junhao Zhao, Junshuai Lv, Hejun Li   +10 more
wiley   +1 more source

Aqueous Zinc‐Based Batteries: Active Materials, Device Design, and Future Perspectives

Advanced Energy Materials, EarlyView.
This review conducts a comprehensive analysis of aqueous zinc‐based batteries (AZBs) based on their intrinsic mechanisms, including redox reactions, ion intercalation reactions, alloying reactions, electrochemical double‐layer reactions, and mixed mechanisms, systematically discussing recent advancements in each type of AZBs.
Yan Ran, Fang Dong, Shuhui Sun, Yong Lei
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Among Patients with RET Fusion–Positive Non‐Small Cell Lung Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom, Aaron C. Tan, Erminia Massarelli, Vivek Subbiah, Valentina Boni, Bruce Robinson, Lori J. Wirth, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Caroline E. McCoach   +11 more
wiley   +1 more source

Integrated Green Biorefinery for the Production of Anthocyanins, Fermentable Sugars, and High Pure Lignin from Miscanthus × giganteus

Advanced Energy and Sustainability Research, EarlyView.
Integrated production of pigments, fermentation sugars, and pure lignin has been investigated for the creation of profitable biorefinery developments. Choline chloride‐based natural deep eutectic solvents possess unique solvent capabilities to interact with plant cell wall components to disintegrate lignin‐carbohydrate complex.
Tirath Raj, Vijay Singh
wiley   +1 more source

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

Aggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu   +10 more
wiley   +1 more source