Results 121 to 130 of about 1,599 (212)

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2151-2156, September 2026.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

A Case of Cytokine Release Syndrome (CRS) Related to Treatment With Lenvatinib Plus Pembrolizumab for Metastatic Clear Cell Renal Cell Carcinoma

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infection and immunotherapy. Due to its nonspecific presentation, distinguishing CRS from other life‐threatening conditions remains challenging.
Kei Nagase, Hiroaki Kakinoki, Kazuki Nakamura, Yukako Yamaguchi, Shuhei Kusano, Yuka Kakinoki, Maki Kawasaki, Kazuma Udo, Shohei Tobu, Mitsuru Noguchi   +9 more
wiley   +1 more source

An open‐label, long‐term extension, multicenter study to evaluate the safety and efficacy of venlafaxine extended release in Japanese outpatients with generalized anxiety disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim This study evaluated the long‐term safety and efficacy of venlafaxine extended release (ER), which has been administered for 52 weeks in Japanese adult outpatients with generalized anxiety disorder (GAD). Methods In this open‐label, long‐term extension, multicenter study, 135 Japanese patients with GAD were enrolled after completing 10 ...
Tempei Otsubo, Koichiro Watanabe, Takeshi Inoue, Ataru Inagaki, Toshiaki Kikuchi, Keisuke Nomoto, Shingo Higa, Yuko Asami, Bin Sun, Kristina Marschall   +9 more
wiley   +1 more source

Electrocardiogram Characteristics and Outcomes in an Adult Congenital Heart Disease Population

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
The electrocardiogram (ECG) is a low‐cost, readily available test that can detect dysrhythmia, chamber enlargement, and ischemia in heart disease patients. ECG features and changes over time are linked to adverse cardiac events and mortality in congenital heart disease populations. Further research is needed to develop ECG‐based risk models.
Seyedeh Somayyeh Mousavi, Cheryl L. Raskind‐Hood, Alexandra Haffner, Chad Robichaux, Lindsey C. Ivey, Reza Sameni, Wendy M. Book   +6 more
wiley   +1 more source

Hamman's crunch—A pathognomonic sign of pneumomediastinum

Equine Veterinary Education, Volume 38, Issue 9, Page e571-e576, September 2026.
Summary Pneumomediastinum, particularly spontaneous pneumomediastinum, is uncommon and presents a diagnostic challenge. In human medicine, auscultation of Hamman's crunch, a crepitant, crunching noise, audible over the cardiac region in synchrony with the heartbeat, is considered pathognomonic for pneumomediastinum.
S. McCullagh, C. R. Daniel, J. A. Keen, N. J. Parkinson, B. C. McGorum   +4 more
wiley   +1 more source

Do or Die: A Rapid‐Fire Tabletop Review of “Must Know” Emergency Medicine Pathologies

AEM Education and Training, Volume 10, Issue 4, August 2026.
ABSTRACT Background Emergency medicine (EM) physicians must rapidly recognize and manage time‐critical conditions; however, standardized methods to teach and assess competency in these scenarios remain limited and resource‐intensive. Objective To develop and implement a low‐resource, standardized tabletop simulation to evaluate EM residents' ability to
Jennifer Yee, Colin G. Kaide, Geremiha Emerson, Kelsey H. Jordan, Sorabh Khandelwal   +4 more
wiley   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

A Comprehensive and Critical Evaluation of Autonomic Nervous System Impairment in Patients with Wilson Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism with heterogeneous hepatic and neurological manifestations. Autonomic nervous system (ANS) involvement in WD is poorly recognized and remains inadequately studied, despite its potential to cause significant morbidity if unrecognized.
Sabyasachi Pattanayak, Niraj Kumar Srivastava, Anand Kumar, Deepika Joshi, Atanu Roy, Sanjeev Kumar Singh, Rajniti Prasad, Suyash Tripathi, Ashish Verma, Ritu Ojha, Varun Kumar Singh, Abhishek Pathak, Rameshwar Nath Chaurasia, Vijaya Nath Mishra, Ibrahim Hussain   +14 more
wiley   +1 more source

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 287-300, August 1, 2026.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source