Results 201 to 210 of about 84,964 (268)

CLLAF SCORE—A New Risk Score for Predicting Atrial Fibrillation in Treatment‐Naive CLL Patients Initiating First‐ and Second‐Generation BTK Inhibitor Therapy

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Background One of the limiting toxicities of BTKi is the development of atrial fibrillation (AF), with an incidence of 3%–16%. Aim This study aimed to identify patients with chronic lymphocytic leukemia (CLL) starting both first‐ and second‐generation BTKis who are at high risk of developing AF using a machine learning approach.
Tamar Tadmor   +3 more
wiley   +1 more source

Lamotrigine promotes reentrant ventricular tachycardia in murine hearts

open access: yesEpilepsia, EarlyView.
Abstract Objective In 2021, the US Food and Drug Administration issued a safety warning concerning lamotrigine use in patients with underlying cardiac disorders. This warning was based on in vitro data that predicted class Ib antiarrhythmic activity for lamotrigine.
Patrícia Dias   +5 more
wiley   +1 more source

Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care

open access: yesEpilepsia, EarlyView.
Abstract In this concept paper, we introduce epilepsy‐heart syndrome as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), recognising that these conditions can each serve as a risk factor for the other owing to a bidirectional ...
Gashirai K. Mbizvo   +3 more
wiley   +1 more source

Potassium current inactivation as a novel pathomechanism for KCNQ2 developmental and epileptic encephalopathy

open access: yesEpilepsia, EarlyView.
Abstract De novo variants in KCNQ2 cause neonatal onset developmental and epileptic encephalopathy (KCNQ2‐DEE; Online Mendelian Inheritance in Man #613720), most often by loss‐of‐function in vitro effects. In this study, we describe a neonatal onset DEE proband carrying a recurrent de novo KCNQ2 variant (c.794C>T; p.A265V) affecting the pore domain of ...
Ingride Luzio Gaspar   +6 more
wiley   +1 more source

Characterization of ventricular tachycardia ablation in end-stage heart failure patients with left ventricular assist device (CHANNELED registry). [PDF]

open access: yesEuropace
van den Bruck JH   +23 more
europepmc   +1 more source

Ectopic thyroid carcinoma in the left atrium in a horse

open access: yesEquine Veterinary Education, EarlyView.
Summary A 25‐year‐old Irish sport horse was presented for investigation of a 7‐day history of apathy and lethargy. Clinical examination revealed tachycardia, tachypnoea, distended, pulsating jugular veins and ventral oedema. Serum biochemistry showed azotaemia.
N. Wolf   +4 more
wiley   +1 more source

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