Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social interaction, team tacit knowledge and transactive memory: empirical support for the agile approach [PDF]
, 2012 The agile principles of social interaction and tacit knowledge were examined in this survey study of 48 software development teams. It was proposed that that team tacit knowledge is created through frequency and quality of social interactions and through
O'Connor, Rory +5 more
core +1 more source
Extended Rationale-Based Model for Tacit Knowledge Elicitation in Requirements Elicitation Context
IEEE Access, 2020 The Requirements elicitation involves knowledge intensive and collaborative activities. Requirements engineering research has proposed a range of knowledge elicitation and requirements gathering techniques, few of which apply specific strategies for ...
Halah Abdulaziz Al-Alshaikh +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Knowledge Management & E-Learning: An International JournalKnowledge sharing is the social interaction through which individuals exchange their tacit and explicit knowledge with others. Tacit knowledge comes from experience, talent, and reflection and is difficult to formalize, transfer, and communicate to ...
Delio Ignacio Castaneda +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The role of tacit knowledge in the construction industry: towards a definition [PDF]
The construction industry is perceived as one of the knowledge-based value creating sectors of the economy; however, it faces many challenges, especially in terms of performance, due to its intrinsic nature.
Pathirage, C. P. +2 more
core +3 more sources
Tacitní znalosti jako most mezi teorií a praxí v pedagogické přípravě budoucích učitelů. Tacit knowledge as a bridge between theory and practice in the domain-general aspect of teacher education. [PDF]
Pedagogická Orientace, 2012 The paper deals with tacit knowledge in the pedagogical component ofteacher education. Tacit knowledge is seen – metaphorically – as a bridge between theory and practice. In the paper, the concept of tacit knowledge is characterised; it is a concept that
Švec Vlastimil
doaj
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Establishing Tacit Knowledge Capture System in Project-Oriented Organizations Based on TOGAF Enterprise Architecture: A Systematic Review [PDF]
کتابداری و اطلاعرسانیObjective: This study seeks to investigate how to establish a tacit knowledge capture system in project-oriented organizations based on TOGAF enterprise architecture. Methodology: Due to few research studies on how to implement enterprise architecture in
Mandana Hayati +4 more
doaj +1 more source