Recent advances, challenges and updates on the development of therapeutics for malaria
EXCLI Journal : Experimental and Clinical SciencesMalaria has developed as a serious worldwide health issue as a result of the introduction of resistant Plasmodium species strains. Because of the common chemo resistance to most of the existing drugs on the market, it poses a severe health problem and ...
Rimmy Nandal +10 more
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Epidemiología y tratamiento de Plasmodium vivax = The epidemiology and treatment of Plasmodium vivax [PDF]
, 2014 [spa] La carga de enfermedad y las muertes relacionadas con la malaria han disminuido a nivel global, principalmente gracias a las mejoras en la implementación de las intervenciones para prevenir y tratar la malaria, y en particular al uso de las ...
Betuela, Inoni
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Epidemiologie und Behandlung der importierten Malaria tropica [PDF]
, 2018 An der Malaria erkranken weltweit ca. 212 Millionen Menschen pro Jahr und ca. 430.000 Todesfälle an Malaria werden pro Jahr registriert. Die Malaria tropica wird durch Reisende und Migranten jedoch auch häufig nach Europa importiert.
Zoller, Thomas
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eLifeIn our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti ...
James A Watson +12 more
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The challenges of malaria elimination in the Asia–Pacific region
Medical Journal of Australia, Volume 221, Issue 4, Page 182-185, August 2024.
Freya JI Fowkes +5 more
wiley +1 more source
eLifeA single 300 mg dose of tafenoquine, in combination with chloroquine, is currently approved in several countries for the radical cure (prevention of relapse) of Plasmodium vivax malaria in patients aged ≥16 years.
Raman Sharma +10 more
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Development of the Stem of Jatropha Multifida Linn as a New Antimalarial Through Erythrocytes Test on Mus Musculus Infected by Plasmodium Berghei [PDF]
, 1991 Introduction : Jatropha multifida Linne is known as Betadin plant by the Bengkulunese. The stem extract of J. multifida has antibacterial activity. This study examined the potential of stem extract of J.
Sundaryono, A. (Agus) +2 more
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Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data. [PDF]
, 2015 BACKGROUND: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin.
d'Alessandro, Umberto +9 more
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Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy [PDF]
, 2016 The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency ...
Achim Porzelle +27 more
core +7 more sources