Results 201 to 210 of about 3,248 (232)
Tafenoquine and G6PD: A Primer for Clinicians [PDF]
Journal of Travel Medicine, 2019 Tafenoquine, an 8-aminoquinoline, is now indicated for causal prophylaxis against all human malarias and as radical curative (anti-relapse) treatment against Plasmodium vivax and Plasmodium ovale. As with other 8-aminoquinolines, tafenoquine causes hemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (hemizygous males and ...
Cindy S Chu, David O Freedman
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Malaria chemoprophylaxis with tafenoquine: a randomised study
Lancet, The, 2000Tafenoquine is an analogue of primaquine with an improved therapeutic and safety profile. It has a long half-life and activity against liver-stage malaria parasites, so may be useful for chemoprophylaxis. In this randomised, double-blind study we assessed the efficacy and safety of tafenoquine in different doses.2144 individuals aged 12-20 years living
Bertrand Lell +2 more
exaly +3 more sources
An Efficient and Sustainable Synthesis of the Antimalarial Drug Tafenoquine
ACS Sustainable Chemistry and Engineering, 2022 An 11-step, 8-pot synthesis of the antimalarial drug tafenoquine succinate was achieved in 42% overall yield using commercially available starting materials. Compared to the previous manufacturing processes that utilize environmentally egregious organic solvents and toxic reagents, the current route features a far greener (as measured by Sheldon's E ...
Rahul D Kavthe +2 more
exaly +3 more sources
Tafenoquine: the new kid on the block
Current Opinion in Infectious Diseases, 2019Purpose of review This is a review of tafenoquine, a new antimalarial drug. Here we examine the recent literature supporting the use of tafenoquine and summarize the opportunities and challenges for its well tolerated use worldwide.
Victor, Chen, Johanna P, Daily
openaire +2 more sources
Tafenoquine: a promising new antimalarial agent
Expert Opinion on Investigational Drugs, 2007Malaria remains an important cause of global morbidity and mortality. As antimalarial drug resistance escalates, new safe and effective medications are necessary to prevent and treat malarial infection. Tafenoquine is an 8-aminoquinoline antimalarial that is presently under development.
Kevin C Kain
exaly +3 more sources
Treatment of acute vivax malaria with tafenoquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005Tafenoquine is an 8-aminoquiniline related to primaquine with pre-clinical activity against a range of malaria species. We treated two acute cases of vivax malaria with tafenoquine (800 mg over three days) alone, instead of conventional chloroquine (1500 mg over three days) and primaquine (420 mg over 14 days).
Nasveld, Peter, Kitchener, Scott
openaire +4 more sources
Tafenoquine: First Global Approval
Drugs, 2018Tafenoquine (Krintafel™, Arakoda™), an orally-active 8-aminoquinoline anti-malarial drug, is a long-acting analogue of primaquine with activity against pre-erythrocytic (liver) and erythrocytic (asexual) forms as well as gametocytes of Plasmodium species that include Plasmodium vivax (P. vivax) and Plasmodium falciparum.
openaire +2 more sources
2010
Tafenoquine (SB252263, previously known as WR 238605) is an investigational 8-aminoquinoline that is being co-developed as an antimalarial medication by Medicines for Malaria Venture and GlaxoSmithKline with the historical support of the US Army. Its structure is 2,6-dimethoxy-4-methyl- 5-([3-trifluoromethyl]-phenoxy)-8-([4-amino-1-methylbutyl] amino ...
openaire +2 more sources
Tafenoquine (SB252263, previously known as WR 238605) is an investigational 8-aminoquinoline that is being co-developed as an antimalarial medication by Medicines for Malaria Venture and GlaxoSmithKline with the historical support of the US Army. Its structure is 2,6-dimethoxy-4-methyl- 5-([3-trifluoromethyl]-phenoxy)-8-([4-amino-1-methylbutyl] amino ...
openaire +2 more sources
8-Aminoquinolines: Primaquine and Tafenoquine
20118-Aminoquinolines are an important class of antimalarial drugs because they are effective against the liver stages of Plasmodium infections and thus are administered for radical cure and presumptive antirelapse therapy against relapsing malaria. In this chapter, we discuss two 8-aminoquinolines, primaquine and tafenoquine.
Norman C. Waters, Michael D. Edstein
openaire +1 more source