Results 161 to 170 of about 9,669,534 (306)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Intra- and inter-specific differences of upper thermal limits in the sand darters (Percidae: <i>Ammocrypta</i>). [PDF]

Conserv Physiol
Firth BL, Holsopple AR, Kuhajda BR, George AL, Drake DAR, Power M.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Local Suppression of <i>Dgat2</i> Augments Fatty Acid Oxidation in Skeletal Muscle in High-Fat Diet-Fed Mice. [PDF]

J Microbiol Biotechnol
Jiyun Y, Park JY, Kwon MG, Kim ES, Oh RH, Seo BB, Bu SY.   +6 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation. [PDF]

J Cell Biochem
Saito H, Sugase K.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

<i>SIRT1</i> rs2394445 associates with serum triacylglycerol lipidomic profile in metabolic dysfunction-associated steatotic liver disease. [PDF]

Front Nutr
Pan Q, Guo CJ, Cao HX, Zheng RD, Mi YQ, Zhang R, Shen F, Xu QY.   +7 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Role of Lipid Molecular Structure in Food Technology and Health. [PDF]

Mol Nutr Food Res
Monnard C, Ran-Ressler RR, Patin A, Marzorati M, Semenova I, Giuffrida F.   +5 more
europepmc   +1 more source