Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
SpaMOAL is a deep learning method that enables accurate spatial domain identification from multi-omics data. [PDF]
PLoS BiolWang J +6 more
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Chemical Derivatization Strategies for Expanding Small Biomolecule Analysis by MALDI-MS. [PDF]
MetabolitesHu X, Wang Q, Lin Y, Wan J.
europepmc +1 more source
Lipid droplets at the interface of plant defense and pathogen exploitation. [PDF]
Front Plant SciArvy N +5 more
europepmc +1 more source
Application of Proximity-Labeling Techniques in Plants: A Review of Successful Cases. [PDF]
Int J Mol SciYang Z, Yang S, Meng Q.
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Olive Oil Quality Analysis and the Detection of Adulterations by GC-MS With Cold EI. [PDF]
J Mass SpectromNeumark B +3 more
europepmc +1 more source
mRNA Display for Identifying Peptide Substrates of Enzymes. [PDF]
BiochemistryTrifonov GM, Sames EC, McAllister TE.
europepmc +1 more source
Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales. [PDF]
PLoS Comput BiolTolkova I +4 more
europepmc +1 more source