Results 131 to 140 of about 708,068 (294)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Technology to Enable People with Intellectual Disabilities and Blindness to Collect Boxes with Objects and Transport Them to Different Rooms of Their Daily Context: A Single-Case Research Series

open access: yesTechnologies
(1) Background: People with intellectual disabilities and blindness tend to be withdrawn and sedentary. This study was carried out to assess a new technology system to enable seven of these people to collect boxes containing different sets of objects ...
Giulio E. Lancioni   +6 more
doaj   +1 more source

A Tree Search Algorithm for Sequence Labeling [PDF]

open access: yesarXiv, 2018
In this paper we propose a novel reinforcement learning based model for sequence tagging, referred to as MM-Tag. Inspired by the success and methodology of the AlphaGo Zero, MM-Tag formalizes the problem of sequence tagging with a Monte Carlo tree search (MCTS) enhanced Markov decision process (MDP) model, in which the time steps correspond to the ...
arxiv  

Blood-volume measurements in cancer using the Cr51 red-blood-cell tagging method [PDF]

open access: bronze, 1956
William A. Reilly   +2 more
openalex   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

open access: yesFEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston   +7 more
wiley   +1 more source

An exploratory analysis of usability of Flickr tags for land use/land cover attribution

open access: yesGeo-spatial Information Science, 2019
This study explored the land use/land cover (LULC) separability by the machine-generated and user-generated Flickr photo tags (i.e. the auto-tags and the user-tags, respectively), based on an authoritative LULC dataset for San Diego County in the United ...
Yingwei Yan   +2 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy