Results 161 to 170 of about 283,830 (296)

Rates of Evolution Differ Between Cell Types Identified by Single-Cell RNAseq in Threespine Stickleback. [PDF]

Mol Ecol
Rodgers ML, Subramanian S, Fuess LE, He W, Scarpino SV, Roth-Monzón AJ, Jeffries DL, Seignon M, Milligan-McClellan K, Carrier R, Steinel NC, Bolnick DI.   +11 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Bromo-desthiobiotin (Br-DTB) tag for unbiased profiling and identification of chemical modifications. [PDF]

RSC Chem Biol
Palai BB, Ramirez DH, Deng C, de Luna Vitorino FN, Zhao C, Zhu D, Lv D, Garcia BA, Lin Z.   +8 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity. [PDF]

Diabetes
Sheng J, Qi S, Chan M, Wang E, Han X, Hsueh WA, Yang L, Wong STC.   +7 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial. [PDF]

Sci Data
Wu Z, Tong Y, Chen W, Chen W, Li L, Huang D, Li Z, Song Z, Cai X.   +8 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fixed Thoracic Lead Tags Are Associated with Distinct Landing-Approach Trajectories in Honey Bees (<i>Apis mellifera</i>). [PDF]

Animals (Basel)
He YZ, Ouyang HD, Li CL, Lu TS, Wu LH, Wu HP, Zhong X, Zhang JW, He XJ.   +8 more
europepmc   +1 more source