Results 221 to 230 of about 1,132,441 (330)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro. [PDF]
EMBO RepDörner K +10 more
europepmc +1 more source
Utility of biological sensor tags in animal conservation
Conservation Biology, 2015 Alexander D. M. Wilson +4 more
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins. [PDF]
J Pept SciMøller DN +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Characterization of the Glutamine Synthetase Gene Family in Wheat (<i>Triticum aestivum</i> L.) and Expression Analysis in Response to Various Abiotic Stresses. [PDF]
Int J Mol SciZhang Z +10 more
europepmc +1 more source