Results 61 to 70 of about 81,086 (272)

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Image-based assessment of tail docking and tail biting in slaughtered pigs across three European countries

Frontiers in Veterinary Science
Slaughterhouse monitoring provides a cost-effective and suitable tool for large-scale surveillance of tail-biting, which is a major welfare issue in pig production.
Anastasia Romano, Simona Baghini, Andrea Capobianco Dondona, Nicola Bernabò, Giuseppe Marruchella   +4 more
doaj   +1 more source

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives : Ligands with mixed NOP and opioid receptor profile [PDF]

, 2018
© 2018 Kumar, Polgar, Cami-Kobeci, Thomas, Khroyan, Toll and Husbands.A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and ...
Cami-Kobeci, Champion, Cheng, Christoph, Ding, Dooley, Greedy, Greiner, Gumusel, Günther, Hu, Huang, Jenck, Khroyan, Khroyan, Kiguchi, Ko, Lewis, Lewis, Lia, Manabe, Meunier, Meunier, Mogil, Mollereau, Moynihan, Pomonis, Raffa, Reinsceid, Rizzi, Rossi, Saccone, Sandin, Schmidhammer, Schmidhammer, Schmidhammer, Spagnolo, Sukhtankar, Thompson, Toll, Toll, Traynor, Ueda, Vanderah, Váradi, Woodcock, Yu, Zeilhofer   +47 more
core   +4 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

More tail lesions among undocked than tail docked pigs in a conventional herd

Animal, 2017
The vast majority of piglets reared in the European Union (EU) and worldwide is tail docked to reduce the risk of being tail bitten, even though EU animal welfare legislation bans routine tail docking.
H.P. Lahrmann, M.E. Busch, R.B. D’Eath, B. Forkman, C.F. Hansen   +4 more
doaj   +1 more source

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]

, 2014
The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D., Milligan, Graeme, Shimpukade, Bharat, Ulven, Trond   +3 more
core   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Producer Perceptions of the Prevention of Tail Biting on UK Farms: Association to Bedding Use and Tail Removal Proportion

Animals, 2019
Tail biting causes widespread problems both for animal welfare and in the form of economic losses in pig production. This study was performed to better understand the perceptions of farmers on how to best prevent tail biting, and if perceptions are ...
Anna Valros, Claire Barber
doaj   +1 more source

Individual behavioral correlates of tail biting in pre-finishing piglets

Frontiers in Veterinary Science, 2022
IntroductionTail biting is a widespread problem in pig production systems and has a negative impact on both animal welfare and farm income. This explorative study aims to validate how tail biting is related to general behaviors at the individual level ...
Marc Bagaria, Marc Bagaria, Laura Kuiper, Ellen Meijer, Elisabeth H. M. Sterck, Elisabeth H. M. Sterck   +5 more
doaj   +1 more source

Visualizing the dynamics of London's bicycle hire scheme [PDF]

, 2011
Visualizing flows between origins and destinations can be straightforward when dealing with small numbers of journeys or simple geographies. Representing flows as lines embedded in geographic space has commonly been used to map transport flows, especially ...
Dykes, J., Slingsby, A., Wood, J.
core   +2 more sources