Results 71 to 80 of about 81,086 (272)
Advanced Science, EarlyView.This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun +17 more
wiley +1 more source
Undocked Tails, Mycoplasma-like Lesions and Gastric Ulcers in Slaughtering Pigs: What Connection?
Animals, 2023 Tail biting is an economical and behavioral problem in the pork production system worldwide and systematic tail docking has been applied for decades to decrease the risk of its onset.
Annalisa Scollo +3 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang +9 more
wiley +1 more source
Italian Journal of Animal Science, 2023 Low space availability, high temperatures and a barren environment may contribute to the occurrence of abnormal behaviours and lesions in intensive pig farming. The present study evaluated the housing conditions (HCs), that influence behavioural measures
Francesco Palumbo +5 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Mechanical/thermal sensitivity and superficial temperature in the stump of long-term tail-docked dairy cows [PDF]
PeerJ, 2018 Background Tail docking of dairy cows is a painful procedure that affects animal welfare level. The aims of this study were first to evaluate the response to mechanical and thermal stimulation, and second to determine the superficial temperature of the ...
Renata J. Troncoso +5 more
doaj +2 more sources
A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions [PDF]
, 2012 Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA ...
Corey W. Hecksel +6 more
core +3 more sources
Advanced Science, EarlyView.This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang +14 more
wiley +1 more source
Tail docking in horses: a review of the issues
Animal, 2007 Routinely performed painful procedures are of increasing interest and, in 2001 (Royal Order, May 17), Belgium prohibited docking in several vertebrates including horses. In 2004, opponents to this decision submitted a Bill (Doc51 0969/001) to Parliament,
D. Lefebvre +3 more
doaj +1 more source
On-Farm Welfare Assessment Protocol for Suckling Piglets: A Pilot Study
Animals, 2020 Piglets experience welfare issues during the nursery phase. This pilot study aimed to test a protocol for identifying the main welfare issues in suckling piglets and to investigate relationships among animal-based indicators and management conditions ...
Marika Vitali +6 more
doaj +1 more source