Results 31 to 40 of about 12,802,658 (263)

Molecular roles and function of circular RNAs in eukaryotic cells

Cellular and Molecular Life Sciences, 2017
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear messenger RNAs, with exons arranged colinearly to their genomic order.
L. Holdt, Alexander Kohlmaier, D. Teupser   +2 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Essential role for SUN5 in anchoring sperm head to the tail

eLife, 2017
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function.
Yongliang Shang, Fuxi Zhu, Lina Wang, Yingchun Ouyang, M. Dong, Chao Liu, Haichao Zhao, Xiuhong Cui, Dongyuan Ma, Zhiguo Zhang, Xiaoyu Yang, Yueshuai Guo, Feng Liu, Li Yuan, F. Gao, Xuejiang Guo, Qing-Yuan Sun, Yunxia Cao, Wei Li   +18 more
semanticscholar   +1 more source

A continuous updating weighted least squares estimator of tail dependence in high dimensions [PDF]

Extremes, 2016
Likelihood-based procedures are a common way to estimate tail dependence parameters. They are not applicable, however, in non-differentiable models such as those arising from recent max-linear structural equation models.
J. Einmahl, A. Kiriliouk, J. Segers
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tail approximations to the density function in EVT [PDF]

Extremes, 2006
For a sequence of i.i.d. random variables which belongs to the domain of max-attraction of an extreme value distribution, the convergence of the PDF of the normalized maxima is investigated. Asymptotic expansions and the rate of convergence in a weighted sup-norm are derived under some second-order conditions.
Hüsler, Jürg, Li, Deyuan
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Proving algorithms by tail functions

Information and Control, 1971
A method for semantic description of algorithms is proposed. The basis of the method is the notion of a “tail function” of an algorithm, describing all possible computations defined by this algorithm. The notion of a characteristic equation for an algorithm is introduced and some relations between these equations and the corresponding tail functions ...
openaire   +2 more sources