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Tail Index Estimation for Discrete Heavy-Tailed Distributions
It is the purpose of this paper to investigate the issue of estimating the regularity index $β>0$ of a discrete heavy-tailed r.v. $S$, \textit{i.e.} a r.v. $S$ valued in $\mathbb{N}^*$ such that $\mathbb{P}(S>n)=L(n)\cdot n^{-β}$ for all $n\geq 1$, where $L:\mathbb{R}^*_+\to \mathbb{R}_+$ is a slowly varying function.
Bertail, Patrice +2 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Heavy-tailed Phenomena and Tail Index Inference
, 2014 This thesis focuses on the analysis of heavy-tailed distributions, which are widely applied to model phenomena in many disciplines. The definition of heavy tails based on the theory of regular variation highlights the importance of the tail index, which indicates the existence of moments and characterises the rate at which the tail decays.
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
A tail-adjusted reliability index for non-Gaussian structural systems
Advanced Modeling and Simulation in Engineering SciencesThe conventional reliability index, although commonly adopted in structural engineering, is constructed under Gaussian assumptions and remains largely insensitive to distributional tail characteristics. As a result, it may significantly underestimate the
Moussa Leblouba +4 more
doaj +1 more source
Regression estimators for the tail index [PDF]
Acta Scientiarum Mathematicarum, 2021 Amenah AL-Najafi +2 more
openaire +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source