Results 51 to 60 of about 5,003,510 (291)
Divergence based robust estimation of the tail index through an exponential regression model [PDF]
Statistical Methods & Applications, 2014 The extreme value theory is very popular in applied sciences including finance, economics, hydrology and many other disciplines. In univariate extreme value theory, we model the data by a suitable distribution from the general max-domain of attraction ...
Abhik Ghosh
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tail index estimation, concentration and adaptivity [PDF]
, 2015 This paper presents an adaptive version of the Hill estimator based on Lespki's model selection method. This simple data-driven index selection method is shown to satisfy an oracle inequality and is checked to achieve the lower bound recently derived by ...
S. Boucheron, Maud Thomas
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Varying Index Coefficient Model for Tail Index Regression
MathematicsInvestigating the causes of extreme events is crucial across various fields. However, existing asymptotic theoretical models often lack flexibility and fail to capture the complex dependency structures inherent in extreme events.
Hongyu An, Boping Tian
doaj +1 more source
Impact of Tail Water Fluctuation on Turbine Start-Up and Optimized Regulation
Energies, 2019 Small hydropower plants are usually run-of-river with a poor adjustment capacity, and, therefore, large tail water fluctuation may be induced during flood discharge.
Sheng Chen +5 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
U-Statistic for Multivariate Stable Distributions
Journal of Probability and Statistics, 2017 A U-statistic for the tail index of a multivariate stable random vector is given as an extension of the univariate case introduced by Fan (2006). Asymptotic normality and consistency of the proposed U-statistic for the tail index are proved theoretically.
Mahdi Teimouri +2 more
doaj +1 more source
Robust estimation of the Pareto tail index: a Monte Carlo analysis
, 2016 The Pareto distribution is often used in many areas of economics to model the right tail of heavy-tailed distributions. However, the standard method of estimating the shape parameter (the Pareto tail index) of this distribution—the maximum likelihood ...
Michał Brzeziński
semanticscholar +1 more source