Results 241 to 250 of about 138,460 (299)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Genomic Map of Escherichia coli and Single Nucleotide Polymorphism Markers in Colorectal Cancer. [PDF]

open access: yesMicrob Biotechnol
Xi Y   +10 more
europepmc   +1 more source

Population-based genome-wide association study of plasma complex lipid species. [PDF]

open access: yesNat Commun
Landstra EN   +6 more
europepmc   +1 more source

The "Bunny Tail" Lesion: An MRI Pattern of Proximal Biceps Femoris Tendon Injury With Rapid Return to Play in Elite Soccer Players-a Retrospective Observational Case Series. [PDF]

open access: yesOrthop J Sports Med
Corsini A   +8 more
europepmc   +1 more source

Welfare and Performance of Finishing Pigs Kept at Two Group Sizes on Ad Libitum vs. Restricted Feeding. [PDF]

open access: yesAnimals (Basel)
Andersen IL   +6 more
europepmc   +1 more source

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