Results 251 to 260 of about 521,883 (320)

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [PDF]

Food Chem X
Zhu H, Zhou K, Li Y, Zhou Q, Peng M, Wu X, Mao X, Yang Q.   +7 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Enhancing polygenic risk prediction by modeling quantile-specific genetic effects. [PDF]

Sci Rep
Kim S, Goo T, Park T, Park M.
europepmc   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Early detection of type 2 diabetes mellitus-associated cognitive dysfunction: The potential of amide proton transfer-weighted imaging. [PDF]

Diabetes Obes Metab
Shao JW, Yang Y, Zhang YQ, Dai HY, Fang J, Booth TC.   +5 more
europepmc   +1 more source

Transparent comparisons of Emergency-Department prioritization policies: integrating tail risk, target attainment, and utility analysis. [PDF]

PLoS One
DeHollander A, Karwan M, Casucci S.
europepmc   +1 more source

Impact of Tumor Localization on Early Recurrence After Curative Resection in Pancreatic Ductal Adenocarcinoma. [PDF]

Medicina (Kaunas)
Caliskan Yildirim E, Unek IT, Oztop I, Uzun M, Unek T, Sagol O.   +5 more
europepmc   +1 more source

In-Plant Assessment of Peruvian Pisco Distillates Using Infrared Sensing Technologies. [PDF]

J Agric Food Chem
Wu Y, Hatta-Sakoda B, Hugo Toledo-Herrera V, Mellado Carretero J, Rodríguez-Saona LE.   +4 more
europepmc   +1 more source

Development and validation of a nomogram for predicting distant metastasis and prognosis in elderly T1-T2 pancreatic ductal adenocarcinoma patients. [PDF]

Discov Oncol
Lu Q, Liu D, Fang J, Xie Y, Zhou X.
europepmc   +1 more source