Results 51 to 60 of about 510,642 (302)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

VaR-implied tail-correlation matrices : [Version October 2013] [PDF]

, 2013
Empirical evidence suggests that asset returns correlate more strongly in bear markets than conventional correlation estimates imply. We propose a method for determining complete tail correlation matrices based on Value-at-Risk (VaR) estimates.
Mittnik, Stefan
core  

Beyond Value-at-Risk : GlueVaR Distortion Risk Measures [PDF]

, 2013
We propose a new family of risk measures, called GlueVaR, within the class of distortion risk measures. Analytical closed-form expressions are shown for the most frequently used distribution functions in financial and insurance applications.
Belles Sampera, Jaume, Guillén, Montserrat, Santolino, Miguel   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A New Reciprocal Weibull Extension for Modeling Extreme Values with Risk Analysis under Insurance Data

Mathematics, 2023
Probability-based distributions might be able to explain risk exposure well. Usually, one number, or at the very least, a limited number of numbers called the key risk indicators (KRIs), are used to describe the level of risk exposure.
Haitham M. Yousof, Yusra Tashkandy, Walid Emam, M. Masoom Ali, Mohamed Ibrahim   +4 more
doaj   +1 more source

Improved estimators of extreme Wang distortion risk measures for very heavy-tailed distributions [PDF]

, 2017
A general way to study the extremes of a random variable is to consider the family of its Wang distortion risk measures. This class of risk measures encompasses several indicators such as the classical quantile/Value-at-Risk, the Tail-Value-at-Risk and ...
Alvarado, Beirlant, Beirlant, Belles-Sampera, Caeiro, Cherny, Csörgő, Csörgő, Davison, de Haan, Deme, Deme, Diebolt, Dowd, Drees, Drees, Drees, El Methni, El Methni, Etemadi, Gardes, Ghosh, Goegebeur, Gomes, Gomes, Gomes, Hill, Hosking, Jones, Koutsoyiannis, Necir, Necir, Peng, Pickands, Rootzén, Smith, Stigler, Stupfler, Stupfler, Vandewalle, Wang, Wang, Wang, Wang, Weissman, Yang   +45 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Tail behavior of sums and differences of log-normal random variables

, 2016
We present sharp tail asymptotics for the density and the distribution function of linear combinations of correlated log-normal random variables, that is, exponentials of components of a correlated Gaussian vector.
Gulisashvili, Archil, Tankov, Peter
core   +1 more source

A consistent estimator to the orthant-based tail value-at-risk [PDF]

ESAIM: Probability and Statistics, 2018
In this paper, we address the estimation of multivariate value-at-risk (VaR) and tail value-at-risk (TVaR). We recall definitions for the bivariate lower and upper orthant VaR and bivariate lower and upper orthant TVaR, presented in Cossetteet al.[Eur. Actuar. J.3(2013) 321–357 orMethodol. Comput. Appl. Probab.(2014) 1–22].
Beck, Nicholas, Mailhot, Mélina
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source