Results 11 to 20 of about 2,782 (143)

Incidence of cancer and related deaths in hemoglobinopathies: A follow-up of 4631 patients between 1970 and 2021. [PDF]

Cancer, 2023
Abstract Background The correlation between thalassemia and malignancies other than hepatocellular carcinoma (HCC) and the possible relationship between other hemoglobinopathies and tumor risk have been poorly evaluated. Methods Eight Italian specialized centers evaluated the incidence of malignant neoplasms in hemoglobinopathies as well as their sites
Origa R, Gianesin B, Longo F, Di Maggio R, Cassinerio E, Gamberini MR, Pinto VM, Quarta A, Casale M, La Nasa G, Caocci G, Piroddi A, Piolatto A, Di Mauro A, Romano C, Gigante A, Barella S, Maggio A, Graziadei G, Perrotta S, Forni GL.   +20 more
europepmc   +2 more sources

Thalassaemia is paradoxically associated with a reduced risk of in-hospital complications and mortality in COVID-19: Data from an international registry. [PDF]

J Cell Mol Med, 2022
Abstract Although numerous patient‐specific co‐factors have been shown to be associated with worse outcomes in COVID‐19, the prognostic value of thalassaemic syndromes in COVID‐19 patients remains poorly understood. We studied the outcomes of 137 COVID‐19 patients with a history of transfusion‐dependent thalassaemia (TDT) and transfusion independent ...
El-Battrawy I, Longo F, Núñez Gil IJ, Abumayyaleh M, Gianesin B, Estrada V, Aparisi Á, Arroyo-Espliguero R, Balocco M, Barella S, Beccaria A, Bonetti F, Casale M, De Michele E, Denotti AR, Fidone C, Fortini M, Gamberini MR, Graziadei G, Lisi R, Massa A, Marcon A, Rubinski B, Miano M, Motta I, Pinto VM, Piperno A, Mariani R, Putti MC, Quota A, Ribersani M, Marziali M, Roberti D, Rosso R, Tartaglione I, Vitucci A, Voi V, Zecca M, Romero R, Marouneld C, Fernández-Rozas I, Espejo C, Marhaeni W, Garcia Aguado M, Cappellini MD, Perrotta S, De Franceschi L, Piga A, Forni GL, Akin I.   +49 more
europepmc   +2 more sources

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S1, Page 17-17, April 2023.
C.Z. Cristina Zuccato, L.C.C. Lucia Carmela Cosenza, G.S. Gianni Sacchetti, R.R. Riccardo Rondanin, D.S. Daniele Simoni, M.P. Marco Prosdocimi, M.L.P. Lipucci di Paola, A.F. Alessia Finotti, R.G. Roberto Gambari, I.L. Ilaria Lampronti   +9 more
europepmc   +2 more sources

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S1, Page 41-41, April 2023.
M.L.P. Lipucci di Paola, L.C.C. Lucia Carmela Cosenza, C.Z. Cristina Zuccato, M.Z. Matteo Zurlo, R.G. Roberto Gambari, A.F. Alessia Finotti   +5 more
europepmc   +2 more sources

Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial

Transfusion, Volume 61, Issue 6, Page 1729-1739, June 2021., 2021
Abstract Background The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences. Study Design and Methods The effects of two types of RCC (RCC‐A, RCC‐B) on transfusion regime were compared in a non‐blinded ...
Maria Rita Gamberini, Monica Fortini, Alice Stievano, Eleonora Calori, Maria Vittoria Riontino, Giovanni Ceccherelli, Donatella Venturelli, Roberta Chicchi, Rino Biguzzi, Francesco Fagnoni, Giuseppina Angela Portararo, Daniela Lasagni, Elena Borotti, Ruggero Buonocore, Maurizio Govoni, Roberto Reverberi   +15 more
wiley   +1 more source

Selecting β‐thalassemia Patients for Gene Therapy: A Decision‐making Algorithm

HemaSphere, Volume 5, Issue 5, May 2021., 2021
This expert opinion originally developed by a panel of the Italian Society of Thalassemias and Hemoglobinopathies (SITE), reviewed and adopted by the European Hematology Association (EHA) through the EHA Scientific Working Group on Red Cells and Iron, has been developed as priority decision‐making algorithm on evidence and consensus with the aim to ...
Donatella Baronciani, Maddalena Casale, Lucia De Franceschi, Giovanna Graziadei, Filomena Longo, Raffaella Origa, Paolo Rigano, Valeria Pinto, Monia Marchetti, Antonia Gigante, Achille Iolascon, on behalf of & Chair of, the EHA Scientific Working Group on Red Cells and Iron, Gian Luca Forni   +13 more
wiley   +1 more source

Long-term treatment with deferiprone enhances left ventricular ejection function when compared to deferoxamine in patients with thalassemia major [PDF]

, 2013
Transfusion and iron chelation treatment have significantly reduced morbidity and improved survival of patients with thalassemia major. However, cardiac disease continues to be the most common cause of death.
Barone, R, Calvaruso, G, Campisi, S, Capra, M, Caruso, V, Casale, M, Ciancio, A, Cianciulli, P, Cuccia, L, D'Ascola, G, Filosa, A, Gagliardotto, F, Gerardi, C, Maggio, A., Pitrolo, L, Prossomariti, L, Rigano, P, Rizzo, M, VITRANO, Angela   +18 more
core   +1 more source

Talassemia e hanseniase

Hansenologia Internationalis, 1983
A talassemia β foi investigada em 165 brasileiros descendentes não miscigenados de italianos, 80 dos quais eram doentes de hanseníase, da forma virchowiana, e 85 estudantes universitários (grupo controle).
Antonio Sérgio RAMALHO, Walter PINTO JÚNIOR, Luis Alberto MAGNA, Bernardo BEIGUELMAN   +3 more
doaj   +1 more source

QUANTIFICAÇÃO DE HEMOGLOBINAS POR CROMATOGRAFIA LÍQUIDA DE ALTA PERFORMANCE DE PACIENTES COM DOENÇA FALCIFORME EM PROGRAMA DE ACESSO EXPANDIDO DO VOXELOTOR NO HEMORIO

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: O Voxelotor é um medicamento novo desenvolvido para o tratamento da Doença Falciforme (DF). Ele se liga à hemoglobina (Hb) e aumenta sua afinidade pelo oxigênio, prevenindo sua polimerização e falcização das hemácias.
RA Louback, ION Cabral, PG Moura
doaj   +1 more source

Serial echocardiographic left ventricular ejection fraction measurements: a tool for detecting thalassemia major patients at risk of cardiac death [PDF]

, 2013
Cardiac damage remains a major cause of mortality among patients with thalassemia major. The detection of a lower cardiac magnetic resonance T2* (CMR-T2*) signal has been suggested as a powerful predictor of the subsequent development of heart failure ...
Angastiniotis, M, Barone, R, Calvaruso, G, Campisi, S, Capra, M, Caruso, V, Chattipakorn, N., Cianciulli, P, Cuccia, L, Elefteriou, A, Filosa, A, Gerardi, C, Hamzac, H, Maggio, A, Mancuso, L, Phrommintikul, A, Pitrolo, L, Prossomariti, L, Rigano, P, Telfer, P, VITRANO, Angela, Walkerc, JM   +21 more
core   +1 more source