Results 31 to 40 of about 13,745 (260)

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Morphometry of talar trochlear surface and its correlation

National Journal of Clinical Anatomy, 2018
Background and objectives: The morphometry of talus represents its biomechanical role in transmission of body weight. The objective of the study was to find the shape of trochlea and its correlation with other articular surfaces.
Suresh Narayanan, Vijisha Phalgunan, Nachiket Shankar   +2 more
doaj   +1 more source

Reconstruction after Talar Tumor Resection: A Systematic Review

Current Oncology, 2022
This systematic review investigated the functional outcomes and complications of reconstruction methods after talar tumor resection. A systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases identified 156 ...
Shinji Tsukamoto, Andreas F. Mavrogenis, Kanya Honoki, Akira Kido, Yuu Tanaka, Hiromasa Fujii, Yoshinori Takakura, Yasuhito Tanaka, Costantino Errani   +8 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Talar Osteochondral Defects

Medicine Science, 2015
Intra-articular ankle injuries to the talar body is one of the common cause of athletic disability that have been estimated to occur in approximately 6.5% of the ankle sprains and commonly affect the dome of the talus.
Gokay Gormeli, Yuksel Ersoy, Cemile Ayse Gormeli   +2 more
doaj   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

THE MAIN CAUSES OF UNSATISFACTORY OUTCOMES OF TREATMENT FOR FOOT INJURIES

Неотложная медицинская помощь, 2018
Background. The foot is a special anatomical structure in its complexity. A large number of articular and ligamentous structures provide effective amortization and adaptation to surface features when walking.
V. O. Kalensky, P. A. Ivanov
doaj   +1 more source

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, EarlyView.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

Biomechanical investigation of the effects of various treatment options on the talus in supination external rotation type 4 ankle injuries with ruptured deltoid ligament: Finite element analysis

Sakarya Tıp Dergisi, 2023
Purpose: The purpose of this study is the biomechanical investigation of the rotation, stress and deformation caused in the talus, under a specific load, by various fixation methods in ankle which has supination external rotation (SER) injury and deltoid
Murat Yaylacı, Yilmaz Güvercin
doaj   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source