Results 221 to 230 of about 1,573,132 (324)

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Harnessing Gut Endocrine Cell Plasticity to Restore Insulin Production. [PDF]

Cells
Ayachi C, Napolitano T, Silvano S, Giorgetti-Peraldi S, Mansouri A, Rapetti-Mauss R, Fofo H, Lepage V, Etasse L, Treins C, Tran L, Collombat P.   +11 more
europepmc   +1 more source

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

Spread of injectate during the transversalis fascia plane block: a preliminary anatomical investigation. [PDF]

J Anesth Analg Crit Care
Ciftci B, Tulgar S, Fazlioglu A, Bilal B, Alver S, Alatli I, Korkmaz AO, Sakul BU, De Cassai A, Ahiskalioglu A.   +9 more
europepmc   +1 more source

Consumer Adoption of Internet of Things

Journal of Consumer Behaviour, Volume 24, Issue 2, Page 673-693, March 2025.
ABSTRACT The Internet of Things (IoT), a pivotal technology in enhancing user connectivity, faces a paradox: its widespread potential yet limited consumer adoption. This study addresses this dichotomy by synthesizing a large‐scale meta‐analytic structural equation modeling (MASEM) and hierarchical linear meta‐analysis (HiLMA) of 2736 effect sizes from ...
Wagner Junior Ladeira, Weng Marc Lim, Fernando de Oliveira Santini, Tareq Rasul, Bernardo Frantz, Jean Carlos de Oliveira Rosa, Mohd Azhar   +6 more
wiley   +1 more source

Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption. [PDF]

Gut Microbes
Chen Y, Du H, Zhou W, Qin M, Li M, Jin Y, Xu Y, Ma C, Xia J, Mo Y, Chen N, Huang H, Li H, Xie Z, Wang P, Hong Y.   +15 more
europepmc   +1 more source

Consumer Acceptance of Conversational Bots: Systematic Literature Review and Meta‐Analysis

Journal of Consumer Behaviour, EarlyView.
ABSTRACT As consumers increasingly rely on conversational bots for daily tasks, evidence surrounding motivations for acceptance remains scattered. A systematic literature review (SLR) was conducted on 64 journal articles published between 2008 and 2024, of which 48 provided sufficient quantitative data for inclusion in a meta‐analysis.
Omar H. Fares, Seung Hwan (Mark) Lee
wiley   +1 more source

MiRNAs: a call to arms that shapes the plasticity of tumor associated macrophages in breast cancer. [PDF]

Front Immunol
Fogazzi V, Cosentino G, Sommariva M, Galardi A, Dell'Orto E, Pupa SM, Taccioli C, Iorio MV.   +7 more
europepmc   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source