Results 61 to 70 of about 1,573,132 (324)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Commonly Used External TAM Variables in e-Learning, Agriculture and Virtual Reality Applications

Future Internet, 2020
In recent years information and communication technologies (ICT) have played a significant role in all aspects of modern society and have impacted socioeconomic development in sectors such as education, administration, business, medical care and ...
Ivonne Angelica Castiblanco Jimenez, L. García, M. Violante, F. Marcolin, E. Vezzetti   +4 more
semanticscholar   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Hierarchical therapeutic potential in the mesenchymal stem cell landscape

Journal of Translational Medicine
Mesenchymal stem cells (MSCs) are heterogeneous and versatile cells comprising distinct subpopulations with varying regenerative potential. MSCs have been widely explored in clinical research owing to their regenerative, tissue trophic, immune modulatory,
Jocelynn R. Pearl, Annette Marleau, Dariel O. Pacheco, Vijay Mahant, J. Christopher Mizer, Patricia Juarez, Ali Asadi, Francesco M. Marincola, Diego Guerena, Edward Clay   +9 more
doaj   +1 more source

Trajectories of Physical Function in Canadian Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objectives We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham, Meghan McPherson, Lillian Lim, Roberta A. Berard, Matthew Berkowitz, Jean‐Philippe Proulx‐Gauthier, Brian M. Feldman, Nicole Johnson, Dax G. Rumsey, Heinrike Schmeling, Lori B. Tucker, Thomas Loughin, Kristin M. Houghton, Jaime Guzman, The CAPRI Registry Investigators   +14 more
wiley   +1 more source

Effects of causal beliefs about gout on public views about gout management: A randomized experimental study

Arthritis Care &Research, Accepted Article.
Objective Despite well‐described biological causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch, Borislav Mihov, Anne Horne, Keith J. Petrie, Gregory D. Gamble, Lachlan Fleck, Nicola Dalbeth   +6 more
wiley   +1 more source

Diagnostic performance of the 2019 ESC pre-test probability and Coronary Artery Disease consortium models in estimating obstructive coronary artery disease

Рациональная фармакотерапия в кардиологии
Aim. To evaluate and compare the diagnostic performance of the 2019 European Society of Cardiology pre-test probability (PTP) model and the coronary artery disease (CAD) consortium basic and clinical models in predicting obstructive CAD in patients with ...
Huy Truong Hoang, Dan Van Buu Do, Thao Le Phuong Nguyen, V. V. Maiskov, Z. D. Kobalava   +4 more
doaj   +1 more source

Algorithms Based on Unions of Nonexpansive Maps

, 2018
In this note, we consider a framework for the analysis of iterative algorithms which can described in terms of a structured set-valued operator. More precisely, at each point in the ambient space, we assume that the value of operator can be expressed as ...
Tam, Matthew K.
core   +1 more source

Examining adoption of mobile internet in Saudi Arabia: Extending TAM with perceived enjoyment, innovativeness and trust

Technology and Society, 2018
Mobile internet represents a breakthrough technology that has derived much attention from mobile organizations and services providers in the Kingdom of Saudi Arabia (KSA).
A. Alalwan, A. Baabdullah, Nripendra P. Rana, K. Tamilmani, Yogesh Kumar Dwivedi   +4 more
semanticscholar   +1 more source

Pentagonal 2D Altermagnets: Material Screening and Altermagnetic Tunneling Junction Device Application

Advanced Functional Materials, EarlyView.
From a database of 170 pentagonal 2D materials, 4 candidates exhibiting altermagnetic ordering are screened. Furthermore, the spin‐splitting and unconventional boundary states in the pentagonal 2D altermagnetic monolayer MnS2 are investigated. A MnS2‐based altermagnetic tunneling junction is designed and, through ab initio quantum transport simulations,
Jianhua Wang, Xingyue Yang, Zongmeng Yang, Jing Lu, Pin Ho, Wenhong Wang, Yee Sin Ang, Zhenxiang Cheng, Shibo Fang   +8 more
wiley   +1 more source