Results 181 to 190 of about 12,699,384 (343)

Identifikasi Daerah Rawan Tanah Longsor Menggunakan SIG (Sistem Informasi Geografis) (Studi Kasus : Kabupaten Kediri)

open access: yesJurnal Teknik ITS, 2017
Indonesia adalah negara yang rawan bencana dilihat dari aspek geografis, klimatologis dan demografis. Letak geografis Indonesia di antara dua benua dan dua samudera menyebabkan Indonesia mempunyai potensi yang bagus dalam perekonomian sekaligus juga ...
Alfi Rohmah Putri
doaj  

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen   +20 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

open access: yesAdvanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider   +14 more
wiley   +1 more source

Processing System and Algorithm for the TanDEM-X Mission [PDF]

open access: yes, 2009
In 2009, the German radar satellite TerraSAR-X will be supplemented with the TanDEM-X satellite to form the first bi-static single pass interferometer in space.
Brcic, Ramon   +7 more
core  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

open access: yesAdvanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes   +14 more
wiley   +1 more source

A Versatile Processing Chain for Experimental TanDEM-X Product Evaluation [PDF]

open access: yes, 2010
TanDEM-X is a high-resolution interferometric mission with the main goal of providing a global digital elevation model (DEM) of the Earth surface by means of single-pass X-band SAR interferometry.
Naninni, Matteo   +6 more
core  

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong   +20 more
wiley   +1 more source

TanDEM-X Close Formation Flight AOCS Safety Measures and Operations [PDF]

open access: yes, 2011
The TanDEM-X project is implemented by a “Public-Private Partnership” between the German Aerospace Centre (DLR) and Astrium GmbH. The primary goal of the TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) mission is to generate a global ...
Schulze, Daniel   +2 more
core  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

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