Results 181 to 190 of about 512,955 (266)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Tandem extracorporeal blood purification therapies for sepsis and acute kidney injury in critically ill children: a state-of-the-art review. [PDF]

Ren Fail
Shirode P, Sethi SK, Nascimento D, Tanna S, Johnson E, Safadi K, Beck T, Bakkaloglu SA, Kirpalani A, Raimer P, Moritz ML, Raina R.   +11 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Smartphone-Based Field Assessment of Trunk Stability and Its Relationship With Whole-Body Balance in Older Adults: Cross-Sectional Study. [PDF]

JMIR Aging
De Los Ríos-Calonge J, Juan-Recio C, Prat-Luri A, Miralles-Iborra A, Elvira JL, Barbado D, Vera-Garcia FJ.   +6 more
europepmc   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Contra-Thermodynamic Chain-Walking Isomerization: A Sustainable Tool for Selective Molecular Editing in Green Chemistry. [PDF]

ChemSusChem
Turczel G, Erdélyi Á, Nagyházi M, Tuba R.   +3 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation. [PDF]

Nat Commun
Thomson G, Poulet A, Huang YC, Liao HS, LeBlanc C, Jacob Y.   +5 more
europepmc   +1 more source

Description of a chromosomal <i>fosA6</i> tandem multicopy fragment and its <i>in vivo</i> evolution in consecutive KPC-producing <i>Klebsiella pneumoniae</i> clinical isolates. [PDF]

Antimicrob Agents Chemother
Mateo-Vargas MA, Fernández-Cuenca F, López-Cerero L, Rodríguez-Iglesias M, Galán-Sánchez F.   +4 more
europepmc   +1 more source