Results 51 to 60 of about 31,885 (149)

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.

, 2010
Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell's repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleotides
O'Neill, P, Eccles, LJ, Lomax, ME, O'Neill, Peter   +3 more
core   +1 more source

Genetic Diversity of PCR-Positive, Culture-Negative and Culture-Positive Mycobacterium ulcerans Isolated from Buruli Ulcer Patients in Ghana.

, 2014
Culture of Mycobacterium ulcerans from Buruli ulcer patients has very low sensitivity. Thus confirmation of M. ulcerans infection is primarily based on PCR directed against IS2404.
Sarfo, S, Stephen Sarfo (521154), Small, P, Phillips, R, Heather Williamson (521153), Pamela Small, Pamela Small (521155), Richard Phillips, Heather Williamson, Wansbrough-Jones, M, Stephen Sarfo, Mark Wansbrough-Jones, Williamson, H, Richard Phillips (205457), Mark Wansbrough-Jones (347902)   +14 more
core   +1 more source

8-Oxo-7,8-dihydro-2′-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA

, 2017
8-Oxo-2′-deoxyguanosine in a tandem lesion context is two orders of magnitude more susceptible to oxidation than in a context of native DNA yielding hydantoin products.
Cynthia J. Burrows, Aaron M. Fleming
core   +1 more source

The T-Top Technique for Tandem Lesions: A Single-Center Retrospective Study

Journal of Clinical Medicine
Background: Tandem Lesions (TLs) or Tandem Occlusions (TOs) are characterized by simultaneous high-grade stenosis or occlusion of the proximal extracranial internal carotid artery and the intracranial terminal internal carotid artery or its branches. These lesions can result in stroke and pose significant challenges to endovascular treatment.
Daniele Giuseppe Romano, Raffaele Tortora, Matteo De Simone, Giulia Frauenfelder, Alfredo Siani, Ettore Amoroso, Gianpiero Locatelli, Francesco Taglialatela, Gianmarco Flora, Francesco Diana, Renato Saponiero   +10 more
openaire   +3 more sources

Revisiting Antiplatelet Therapy in Acute Carotid Tandem Lesions

Journal of Clinical Medicine
Background/Objectives: Acute carotid tandem lesions (TLs), defined by concurrent cervical internal carotid artery (ICA) stenosis or occlusion and intracranial large vessel occlusion, occur in 10–20% of patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke (AIS). Optimal periprocedural antiplatelet management during emergent carotid
Matija Zupan, Lara Straus, Pawel Kermer, Panagiotis Papanagiotou, Senta Frol   +4 more
openaire   +1 more source

Tandem Lesions in Anterior Circulation Stroke: Analysis of the German Stroke Registry-Endovascular Treatment

, 2021
Background and Purpose: Tandem lesions in the anterior circulation account for up to 30% of all large vessel occlusion strokes. The optimal periprocedural approach in these lesions is still a matter of debate.
Herzberg, M., Feil, K., Thunstedt, D.C., Liebig, T., Dimitriadis, K., Dorn, F., Küpper, C., Tiedt, S., Kellert, L., Papanagiotou, P., Kastrup, A., Meyer, L., Dieterich, M.   +12 more
core  

Tandem lesion (cerebrovascular)

, 2020
Frank Gaillard, Rohit Sharma
openaire   +1 more source

Instantaneous Wave-Free Ratio and Resting Pd/Pa in Tandem Lesions

JACC: Cardiovascular Interventions, 2018
Kikuta et al. [(1)][1] should be commended for demonstrating a good correlation between instantaneous wave-free ratio (iFR) pullback prediction and actual observation of post-percutaneous coronary intervention iFR.
openaire   +2 more sources

An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli.

, 2007
Ionizing radiation induces clustered DNA damaged sites, defined as two or more lesions formed within one or two helical turns of the DNA through passage of a single radiation track. It is now established that clustered DNA damage sites are found in cells
Lomax, ME, O'Neill, Peter, Cunniffe, SM
core   +1 more source

Mutagenesis and Repair of γ-Radiation- and Radical-Induced Tandem DNA Lesions

Ionizing radiation induces many different types of DNA lesions. But one of its characteristics is to produce complex DNA damage, of which tandem DNA damage has received much attention, owing to its promise of distinctive biological properties.
Laureen C. Colis, Jan Henric T. Bacurio, Ashis K. Basu   +2 more
core   +1 more source