Results 161 to 170 of about 259,902 (261)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Connect Coordination Victoria and the Establishment of a State-Wide Network of Family Carer Mental Health and Well-being Connect Centres: Family Carer Lived Experience Leadership Through Online Community Co-Design, Communities of Practice and Power Sharing. [PDF]

Health Expect
Phillips J, Casaceli L, Fleming C, Bite J, Walters C, Tilkeridis J, Piu M, Petrakis M.   +7 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Nonmetallic Si Doping Constructs Cu₂O/Co-O-Si Tandem Sites for Neutral Nitrate Reduction Electrocatalysis Toward Ammonia Recovery and Energy-Integrated Applications. [PDF]

Angew Chem Int Ed Engl
Zhao K, Sun Y, Yang X, Pu J, Shi Y, Chen P, Yang J, Yu F.   +7 more
europepmc   +1 more source

Precise Management of n‐Value Distribution at the 2D/3D Interface Enabling Efficient Wide‐Bandgap Perovskite Solar Cells

Advanced Science, EarlyView.
This study elucidates the phase transition pathway of surface‐engineered perovskite films. During spin‐coating, n = 1 2D perovskite dominantly forms, while subsequent annealing drives OA+ release and induces conversion to higher n‐value 2D phases.
Yajie Yang, Jiaxin Ha, Yang Zhang, Yunfan Wang, Ting Jiang, Jingquan Zhang, Lili Wu, Wenwu Wang, Guanggen Zeng, Baoyan Fan, Mohammad Abdul Halim, Xia Hao, Dewei Zhao   +12 more
wiley   +1 more source

Research Progress on Template Methods for Perovskite Nanomaterials in Solar Energy Conversion. [PDF]

Molecules
Li J, Du Z, Du J.
europepmc   +1 more source

Deep‐Learning‐Driven High‐Fidelity In Vivo Hyperspectral Fluorescence Imaging Under Extreme Photon‐Limited Conditions

Advanced Science, EarlyView.
Highly overlapping fluorescent signals become distinguishable in photon‐limited living organisms via advanced imaging with intelligent reconstruction. The resulting in vivo hyperspectral imaging capability reveals nanoplastic uptake and circulation in live zebrafish, providing a new approach for studying complex biological and environmental processes ...
Renjian Li, Shutao Wu, Kaixiang Li, Zhenyu An, Yuwen Ben, Guiye LI, Sunil Kumar, James Mcginty, Tawfique Hasan, Songnian Fu, Meng Zhang, LingLing Chen   +11 more
wiley   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Trace Analysis of Genotoxic Impurity 3-Amino-N-Nitrosopiperidine in Alogliptin Benzoate by Ultra-Sensitive Liquid Chromatography Tandem Mass Spectrometry. [PDF]

Biomed Chromatogr
Gharat MM, Roy PT, Gosar AN, Shaikh TA, Shendage SS, Mirgane NA.   +5 more
europepmc   +1 more source