Results 221 to 230 of about 251,847 (293)

Advancing Malic Acid Production of Aspergillus oryzae: Combined Process Optimization and Application of Various Substrates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In light of climate change and growing resource scarcity, microbial production of organic acids offers a sustainable alternative to fossil‐based chemical synthesis. In this study, malic acid production by Aspergillus oryzae was optimized through cultivation temperature adjustment and biotin supplementation, while organic acid formation from ...
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Björn Vater, Thomas Hahn, Susanne Zibek, Katrin Ochsenreither   +6 more
wiley   +1 more source

Herd-level prevalence of Mycoplasma bovis antibodies in bulk tank milk samples in Austrian dairy herds and risk factors associated with herd seropositive status. [PDF]

Vet Res Commun
Laschinger J, Wieser H, Hoop P, Lyrakis M, Wittek T, Spergser J, Lichtmannsperger K.   +6 more
europepmc   +1 more source

Asymmetric Dialysis: Truly Unified and Simultaneous Single‐Pass Concentration and Buffer Exchange

Biotechnology and Bioengineering, EarlyView.
Asymmetric dialysis, a novel one‐step continuous process combining ultrafiltration and diafiltration, achieves high product concentrations (up to 200 g/L) with low pressures and reduces buffer consumption by 75% compared to conventional methods. This sustainable, low‐cost technology demonstrates significant potential for integration into continuous ...
Ujwal Patil, Michelle Chen, Irina Ramos, Jon Coffman   +3 more
wiley   +1 more source

Nutritional adaptation in the marine to freshwater establishment process - how do diet and genotype shape phenotype? [PDF]

J Exp Biol
Twining CW, Hudson CM, Bravničar J, Carosi A, Denys GPJ, Feulner PGD, Fišer Ž, Rosinger H, Saladin V, Zanella L, Zanella D, Peichel CL, Matthews B.   +12 more
europepmc   +1 more source

Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed‐Batch Fermentation Using Reinforcement Learning

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli, Sakib Ferdous, J. Michael Hess, Nigel F. Reuel   +3 more
wiley   +1 more source

Engineering Pseudomonas taiwanensis VLB120 for regio- and stereospecific hydroxylation of L-lysine fueled by the Weimberg pathway. [PDF]

Microb Cell Fact
Nerke P, Handke J, Hubmann G, Lütz S.
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Characterization of novel pesti- and astro-like viruses in hatchery-reared European seabass (Dicentrarchus labrax) associated with health disorders and low mortality. [PDF]

Vet Res
Louboutin L, Cabon J, Grippon P, Beven V, Hirchaud E, Jamin M, Boitard PM, Blanchard Y, Morin T.   +8 more
europepmc   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Elemental composition of vaping and smoking aerosols: Influence of liquid type and tank conditions. [PDF]

PLoS One
Chwał J, Filipowska A, Antonowicz M, Lisicki D, Kostka P, Doniec R.   +5 more
europepmc   +1 more source