Results 21 to 30 of about 1,314,446 (353)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Legal Protection of Song Copyrights in Digital Form

open access: yesMedia Iuris, 2020
The development of advanced technology and faster, ease of accessing the virtual world leads to equal public access to information collected on the internet, one of which is a song, a recording of rhythmic sound that was originally shaped physics from ...
Chrisna Arwiandra Leuwol   +2 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Study of Practical Method for International 10∼20 Electrode System

open access: yesKorean Journal of Clinical Laboratory Science, 2021
Electroencephalography (EEG) is used for the diagnosis of epilepsy and testing the brain function. Clinical technologists are responsible for recording EEG without artifacts in accordance with the international 10∼20 electrode system.
Sung-Hee Kim, Ok-Kyoung Lee, Dae Jin Kim
doaj   +1 more source

Optically activated magnetic recording tape [PDF]

open access: yes, 1970
Optically activated data storage medium visually and electromagnetically reproduces a recorded signal. In an electric field, particles in heat-fluidized thermoplastic layer form a visible image of the recorded signal. Refluidizing the thermoplastic layer
Marks, A. M., Shulman, A. R.
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Visualization of change of sound characteristics on the level of the vocal cords

open access: yesSouth African Journal of Communication Disorders, 1973
The construction is reported of an apparatus for producing short stroboscopic films, employing a new phase-shifting device. This apparatus provides the clinician with a reliable record of the mode of vibration of the vocal cords (in both the opening and ...
R. Luchsinger
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

E-version

open access: yesCovenant Journal of Engineering Technology, 2018
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any meams, electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without the prior ...
Editor-in-Chief: Dr. Olugbenga Omotosho   +1 more
doaj   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

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