Results 51 to 60 of about 386,573 (306)

Harry Potter and the Glottal Stop: Glottal Replacement and T-Voicing in Contemporary RP [PDF]

Filolog, 2018
The aim of this paper is to highlight the extent of advance made by T-glottalling and T-voicing in younger RP (Received Pronunciation) speakers. The scope of the research extends no further than two speakers, actors Daniel Radcliffe and Emma Watson, with
Andrej Ž. Bjelaković
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Interactions with a photonic crystal micro-cavity using AFM in contact or tapping mode operation [PDF]

, 2006
In this paper we show how the evanescent field of a localized mode in a photonic crystal micro-cavity can be perturbed by a nano-sized AFM tip. Due to the high field intensities in the cavity, we can see a significant change in output power when the tip ...
Bogaerts, W., Hollink, A.J.F., Hopman, W.C.L., Ridder, R.M. de, Subramaniam, V., Werf, K.O. van der   +5 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Operation and control of a current source converter series tapping of an LCC-HVDC link for integration of offshore wind power plants [PDF]

, 2016
This work presents a series tapping station for integrating Offshore Wind Power Plants (OWPP) into a (Line Commutated Converter High Voltage Direct Current) LCC-HVDC transmission system.
Galceran Arellano, Samuel, Gomis Bellmunt, Oriol, Prieto Araujo, Eduardo, Sau Bassols, Joan   +3 more
core   +2 more sources

Characterization of Nitinol Produced by Laser Powder Bed Fusion for Mechanical Metamaterial Applications

Advanced Engineering Materials, EarlyView.
Stabilization of L‐PBF Ni50.7Ti49.3 under low‐cycle loading was investigated. Recoverable strain after cycling was dependent on the amount of applied load. Recovery ratio was 53.4% and 35.1% at intermediate and high load, respectively. The maximum total strain reached 10.3% at a high load of 1200 MPa.
Ondřej Červinek, Jakub Hurník, Miroslav Šmíd, Ondřej Zobač, Melanie Todt, Daniel Koutný   +5 more
wiley   +1 more source

Some considerations concerning the panel management in rubber tapping (Hevea brasiliensis) [PDF]

, 2006
Research devoted to long term panel management deserved less efforts, mainly due to the long duration required for experimentation. The present study deals with the comparison of two panel management strategies on nine clones tapped in 1/2S, over a total
Doumbia, Amadou, Eschbach, Jean-Marie, Gabla, O.R., Gnagne, Michel Y., Gohet, Eric, Lacote, Régis, Obouayeba, Samuel   +6 more
core  

Time Dependent Local Field Distribution and Metastable States in the SK-Spin-Glass

, 2007
Different sets of metastable states can be reached in glassy systems below some transition temperature depending on initial conditions and details of the dynamics.
Aspelmeier, Berg, Cavagna, Cavagna, Coolen, Crisanti, Crisanti, Crisanti, Dean, Eastham, Edwards, H. Horner, Horner, Horner, Kirkpatrick, Kirkpatrick, Kirkwood, Müller, Oppermann, Pankov, Parisi, Sherrington, Sommers, Sompolinsky, Tanaka   +24 more
core   +2 more sources